Mark, When you use EVID =3, you reset the system. Time should be set to whatever time appears at the new event.(0 in your case). This option is usually used in inter occasion study within an individual record.
If you use EVID=4, you reset the system and introduce an new dose record. It is identical to EVID=3 plus EVID=1. ID TIME EVID... 1 0 1 1 1 0 ... ... ... 1 0 4 is the same as ID TIME EVID... 1 0 1 1 1 0 ... ... ... 1 0 3 1 0 1 Xia Li Xia Li Department of Mathematical Science University of Cincinnati From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On Behalf Of Mark Gutierrez Sent: 2008年9月24日 14:11 To: [email protected] Subject: Re: [NMusers] dataset codification Dear all, First of all, thank you for your prompt reply. Following with my doubts. In my case where the time between first and second dose is two months, I understand that I could substitute in Time column the real time (24hours * 2 months) by 0 when the second dose is administered. Is that correct? Or as you mentioned I should include the real time ID TIME EVID... 1 0 1 1 1 0 ... ... ... 1 0 4 ... ... ... On the other hand, In the help guide, when the interoccasion variability example is described, the dataset is arranged with EVID = 3 including an extra line previous to the second dose (second occasion) and restarting TIME with 0 ID TIME EVID... 1 0 1 1 1 0 ... ... ... 1 0 3 1 0 1 1 1 0 ... ... ... This could be another solution to my problem. Isn’t it? Thank you again. Mark ----- Mensaje original ---- De: Sébastien Bihorel <[EMAIL PROTECTED]> Para: "Willavize, Susan A" <[EMAIL PROTECTED]> CC: Mark Gutierrez <[EMAIL PROTECTED]>; [email protected] Enviado: miércoles, 24 de septiembre, 2008 19:03:43 Asunto: Re: [NMusers] dataset codification You are right Susan: the Time values have to increase within a subject. Using EVID=4 allows you to use a more convenient time scale ex: ID TIME EVID... 1 0 1 1 1 0 ... ... ... 1 24 4 ... ... ... instead of ID TIME EVID... 1 0 1 1 1 0 ... ... ... 1 26546 1 ... ... ... Assuming you don't have any measurement after 24h during the first period of your study. Willavize, Susan A a écrit : I have seen EVID=4 used, but don’t remember the details. How does the time variable look? I always convert Date and time to a time counting variable that starts at 0 time (time of first dose) and always increases within each subject. I recall that when EVID= 4 is used, the time variable does NOT need to restart with the second dose. Do I remember correctly? Note I do not include DATE and clock TIME in my NONMEM input, since I have seen NONMEM do nefarious things with these. Susan _____ From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On Behalf Of Sébastien Bihorel Sent: Wednesday, September 24, 2008 5:52 AM To: Mark Gutierrez Cc: [email protected] Subject: Re: [NMusers] dataset codification Dear Mark, You may want to read about "EVID" in the html help. EVID = 4 is what you mean. It is a dosing event but implies that the system is reset before the dose is introduced into the system. Sebastien Mark Gutierrez a écrit : Dear all, I am modeling some PK data from one rabbit. And I have some doubts how to codify the dataset. The rabbit received different single doses of a drug at different times. E.g, First of May it received a 100 mg dose i.v. , Then, 2 months latter (enough washout period), the first of July, it received and oral dose of 100mg.. Finally, after other two months the rabbit received the last oral dose 200mg. I could codify in the TIME column the real times, including the jumps of two months, but I think that there is an option in Nonmem to “restart” the dose through the dataset. Could somebody clarify me this point? and perhaps include a simple example of dataset. Thank you in advance Mark
