Dear Susan:
We have no problem to run CWRES in xpose4 with NONMEM 6.2. But we did
not try the same code with NONMEM 6.1.
We made some changes to the control stream for nm 6.1 before running nm
6.2 as follows:
1) remove the "LAST block
2) change the $TABLE for FILE=cwtabx.deriv to take out all the "COM(x)="
Best regards,
Sam Liao
Pharmax Research
Hi, Everybody,
I have used Andrew Hooker's code to calculate CWRES with NONMEM 6.1
before (the NONMEM verbatim code and the R code for calculation). Now
our NONMEM has been upgraded to 6.2, and I am having problems with the
calculation of CWRES using the same code. In my NONMEM code, for the
error structure I used the following code for the combined error model
$SIGMA
1 FIXED
...
$PK
...
PERR=THETA(5)
AERR=THETA(6)
...
$ERROR
Y=F+(F*PERR + AERR)*EPS(1)
with NONMEM 6.1 and 6.2 using the exact same control file (with the
verbatim code for generating the matrices used for CWRES calculation
included), the outputs of the matrices are different. When using
NONMEM 6.1, the output sigma and sesigma matrices used for calculation
of CWRES are non zero, and the NONMEM 6.2 outputs for these matrices
are zero matrices. The zero matrices seems to be one of the problems
in calculation of CWRES.
I saw in one thread that Tom Ludden mentioned that NONMEM 6.2 can
output the matrices used for calculation of CWRES directly in table
format without using the verbatim code. Has anybody used that function
in 6.2 and would be willing to share the code.
Any help would be much appreciated.
Regards,
Susan
