Hi Ayyappa, Your understanding is correct that the objective functions from FOCEI and FO can not be compared. Regards, Ziad Dr Ziad Hussein Senior Director, Pharmacometrics ICON Development Solutions Manchester United Kingdom
________________________________ From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On Behalf Of [EMAIL PROTECTED] Sent: 10 December 2008 14:40 To: [EMAIL PROTECTED]; [email protected] Subject: [NMusers] OFV higher with FOCEI than FO Dear All, I am analyzing a data set pooled from 4 clinical studies with rich sampling. When I fit a 2 comp oral absorption model with lag time using FO, I got successful minimization with COV step, but minimization was not successful when I used FO parameter estimates as initial estimates for FOCE run. When I used FOCE with INTER minimization was successful with COV step but the OFV is much higher (~25000 vs 20000) with FOCEI estimation than FO. The parameter estimates make more sense with FOCEI than FO. My questions are, Can we get something like this or I am missing something here? Can we compare OFV between different estimation methods (my understanding is no and OFV in case of FO does not make a lot of sense)? Regards, Ayyappa Chaturvedula GlaxoSmithKline 1500 Littleton Road, Parsippany, NJ 07054 Ph:9738892200 ICON plc made the following annotations. ------------------------------------------------------------------------------ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835
