Just consider the sublingual admin to be an extravascular dose. ADVAN2 has a depot for extravascular dosing.
-----Original Message----- From: [email protected] [mailto:[email protected]] On Behalf Of Varsha Mehta Sent: Thursday, January 15, 2009 12:41 PM To: [email protected] Subject: [NMusers] ADVAN 1 or ADVAN 2 for sublingual data Group: I am trying to run a POPPK analysis on sublingual data for pediatric patients. NONMEM is very new for me. I am debating whether it is appropriate to use ADVAN 1 or ADVAN2 for subligual administration. Neither fit the concept perfectly. Should the CTL streams be modified in any way? Thanks in advance. Varsha Mehta, MS(CRDSA), Pharm.D., FCCP Clinical Associate Professor Pharmacy, Pediatrics and Communicable Diseases Clinical Pharmacist Neonatal Critical Care University of Michigan (O) 734-936-8985 (F) 734-936-6946 [email protected] ********************************************************** Electronic Mail is not secure, may not be read every day, and should not be used for urgent or sensitive issues ICON plc made the following annotations. ------------------------------------------------------------------------------ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835
