Temporary position as Pharmacometrician/Pharmacokineticist within the in-vivo section, DMPK, at AstraZeneca R&D Södertälje. The Arena AstraZeneca is one of the top 10 pharmaceutical companies whose success is built upon good science and innovation and we have an exciting discovery portfolio. In Södertälje, the discovery research is focussed on CNS and Pain Control. At the DMPK department, we are involved in project work from project generation to CD selection with the screening and characterization of in vitro and in vivo ADME properties of compounds. The in vivo section supports in vivo pharmacokinetics and provides pharmacokinetic-pharmacodynamic (PK/PD) analysis to the projects. We are now looking for a Pharmacometrician/Pharmacokineticist to join our team in Södertälje. The Role You will participate in the screening process of chemical compounds in drug discovery with regards to pharmacokinetics and you will be involved in establishing PKPD (pharmacokinetics-pharmacodynamic) relationships. Planning, coordination as well as active participation in studies is part of your work, and you will be responsible for gathering and presenting the study results to project teams. Furthermore, you will be working with understanding of the correlation between in-vitro and in-vivo ADME properties and the relationship between pharmacokinetics and pharmacodynamic responses including biomarkers for mechanism of action. Collaboration with other team members and other researchers within and outside AstraZeneca R&D is key in our drug discovery process, which means that you need to be able to represent the department on scientific meetings and at project presentations. Requirements * You have a PhD in pharmaceutical sciences. * You have previous work experience within pharmacokinetics and understand the physiological mechanisms behind absorption, distribution, metabolism and excretion. * Previous experience with PK and PKPD (in pre-clinical phase) as well as in-vitro and in-vivo ADME assays is needed. * The applicant should have a good working knowledge in spoken and written English * Experience with WinNonLin, Nonmem and Berkeley Madonna Success factors * Capability to develop own work tasks * Good written and oral communication skills * Result driven * High degree of flexibility * Structured way of working * Works collaboratively * Problem solving More Information Applications should go via www.astrazeneca.com, carreers, sweden, english vacancies: Pharmacometrician/Pharmacokineticist, temporary-SOD000000IZ SE-Sodertalje For more information please contact: Annette Persson (+46 8553 27507) or Janet Hoogstraate (+46 8553 25810). We would like your application no later than March 29, 2009.
