Dear NMUsers
I am trying to analyse time to single event data using NONMEM VI. I am
getting the following termination message. If some body could point out
what I am doing wrong or may be elaborate on the error message that would
be very helpful.
Thanks in advance
Anubha
0PROGRAM TERMINATED BY OBJ
ERROR IN CLIK WITH INDIVIDUAL 1 ID=0.40000000E+01
CONDITIONAL LIKELIHOOD FOR DATA FROM OBS RECORD 1
ESTIMATED TO BE NEGLIGIBLE
MESSAGE ISSUED FROM ESTIMATION STEP
AT INITIAL OBJ. FUNCTION EVALUATION
Data set
C | STUD | I | TIME | CS | DOSE
| | D | | |
--------------+-----------+----+--------+--------+--------
. | 101 | 4 | 111 | 0 | 0.4
--------------+-----------+----+--------+--------+--------
. | 101 | 5 | 51 | 0 | 0.4
--------------+-----------+----+--------+--------+--------
. | 101 | 6 | 31 | 0 | 0.8
--------------+-----------+----+--------+--------+--------
C Missing | 101 | 7 | . | . | 0.8
DV | | | | |
--------------+-----------+----+--------+--------+--------
. | 101 | 8 | 59 | 0 | 1.6
--------------+-----------+----+--------+--------+--------
. | 101 | 9 | 477 | 1 | 3.2
--------------+-----------+----+--------+--------+--------
. | 101 | 1 | 278 | 0 | 3.2
| | 1 | | |
--------------+-----------+----+--------+--------+--------
. | 101 | 1 | 58 | 0 | 6.4
| | 2 | | |
CS=1 is the censored event
TIME is in days
Model file:
$PROB Time To Event data
$INPUT C STUD ID TIME=DV CS DOSE
$DATA
IGNORE=C
$SUBR ADVAN=6 TOL=6
$MODEL COMP=(RISK)
$PK
BASE = THETA(1)*EXP(ETA(1)) ;the ETA is a placeholder here
$DES
DADT(1)=BASE ;hazard
$ERROR
HZ = A(1) ;hazard
SUR = EXP(-HZ) ;survival probability
DENS=HZ*SUR
Y = (1-CS)*DENS + CS*SUR
$THETA (0,.025) ; BASE;
$OMEGA 0 FIX
$ESTIM MAXEVAL=9990 METHOD = COND LAPLACE LIKE PRINT=1 MSFO=msfb01
$COV PRINT=E
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