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Associate Director / Group Lead, Drug Metabolism Location: Cambridge MA USA Infinity Pharmaceuticals is an innovative cancer drug discovery and development company that is seeking to leverage its strength in small molecule drug technologies to discover, develop, and deliver to patients first-in-class or best-in-class medicines for the treatment of cancer and related conditions. Position Deliverables: The position requires an understanding of the theory and practice of in vitro and in vivo drug metabolism studies. The individual, with supervision, will primarily design and perform a variety of drug metabolism studies in support of our drug discovery and development efforts. Hands-on experience with enzyme phenotyping, metabolite structural elucidation, and CYP450 inhibition is strongly desired. Knowledge of pharmacokinetic principles is desirable as the individual may provide support as needed. The successful candidate will be responsible for applying different scientific skills including assay development and LC-MS/MS operation. The selected individual will work closely with DMPK team members to analyze and interpret data which will be presented in a multidisciplinary team environment. Qualities vital to our success include flexibility, open communication, and teamwork. Position Requirements: * MS/PhD in Analytical Chemistry, Biochemistry or related field with 5-10 years experience. * Extensive experience with a variety of drug metabolism studies, e.g. metabolic stability and metabolite profiling in microsomes, hepatocytes or biological samples from in vivo studies. * Experience in LC-MS/MS operation, method development, maintenance, and troubleshooting. * Strong interpersonal skills. * Strong oral and written communication skills. Interested candidates may apply online at: http://www.infi.com/careers.html _____________________ This email has been scanned by the MessageLabs Email Security System to prevent the transmission of viruses, spam and other unwanted content.
