Try $COVARIANCE UNCONDITIONAL This will give you a standard error from the METHOD=IMP EONLY=1 step even if there is some positive indefiniteness. But, be cautious about its quality when such a message occurs.
Robert J. Bauer, Ph.D. Vice President, Pharmacometrics ICON Development Solutions Tel: (215) 616-6428 Mob: (925) 286-0769 Email: [email protected] Web: www.icondevsolutions.com ________________________________ From: [email protected] [mailto:[email protected]] On Behalf Of [email protected] Sent: Wednesday, December 02, 2009 9:57 AM To: [email protected] Subject: [NMusers] Standard errors using SAEM Hi everyone; I am currently performing an analysis where I am starting with iterative two-stage, then SAEM, and finishing off with importance sampling. Here is the relevant code: $ESTIMATION METH=ITS INTERACTION NSIG=3 SIGL=6 CTYPE=3 NOABORT NITER=100 FILE=RUN19.TTS PRINT=15 $ESTIMATION METH=SAEM INTERACTION NOABORT CTYPE=3 NBURN=300 NITER=800 FILE=RUN19.SAE PRINT=15 $ESTIMATION METH=IMP INTERACTION ISAMPLE=1000 NITER=10 EONLY=1 FILE=RUN19.IMP $COVARIANCE $TABLE ID TIME AGE WT SEX CLR CL V2R V2 V3R V3 EWRES CWRES NPDE CPRED PREDI CPREDI MDV ETA1 ETA2 ETA3 ETA6 FILE=RUN19.CSV FORMAT=,1PE7.4 ONEHEAD NOPRINT I notice that I am not getting standard errors for any of these runs, except after the iterative two-stage portion of the analysis, which are not especially useful. Can anyone shed some light as to what I am leaving out of my code? I have been through the documentation and can not find what I am doing wrong, although it is possible (likely!) that I am missing something. Thanks, Mike Fossler GSK ICON plc made the following annotations. ------------------------------------------------------------------------------ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835
