Dear All,
I am looking for a help. Currently I am working on a population PD model to
evaluate the effects of drugs on QT prolongation. Drug A and drug B are given
to the study subjects (healthy volunteer) at the same time. Drug B is the
inhibitor for the metabolism of drug A, also compound C is the metabolite of
drug A. I am wondering how to evaluate the effects for drug A or B or the
metabolite of drug A (compound C). These three moieties will be present
together in the blood for most of the time. Is anyone has experience and would
like to share with us. Any comment will be greatly appreciated.
Best regards,
Yuhong
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