Dear all,
I wonder how to deal with different infusion schedules. In my dataset the 24
hour infusions were given in two different regimens:
One was to infuse 10% of the dose for 5 minutes followed by an 23:55 h infusion
of the rest of the dose. The other was to infuse the 10% in the beginning for
one hour followed by an 23 h infusion of the remaining 90% of the dose. 4 hour
infusions were given in only one infusion.
I set up the data file as follows:
The dose time is at 10 to put the pre-dose PD-measurement in front.
ID TIME RATE AMT DOSE DUR MDV
PD-MDV DV PD-DV
1 0 0 0 0
0 1 0 . [value]
1 10 [AMT/DUR] [0.1*DOSE] [value] 0.083 1 1
. .
1 10.083 [AMT/DUR] [0.9*DOSE] [value] 23.92 1 1
. .
1 14 0 0 [value] 0
0 0 [value] .
...
For the model I use an ADVAN3 subroutine with TRANS4.
Alternatively I tried to put this in a $PRED routine but with two record for
each rate and two records for each duration, which lead to different results.
Did I manage the data right and how can I see my Amount in the compartment if I
don't use differential equations?
-----------------------------
Hauke Rühs
Apotheker
Pharmazeutisches Institut
- Klinische Pharmazie -
An der Immenburg 4
53121 Bonn
Tel: + 49-(0)228 73-5781
Fax: + 49-(0)228 73-9757
<http://www.klinische-pharmazie.info/> www.klinische-pharmazie.info
