-----Original Message----- From: Ludden, Thomas Sent: Friday, April 16, 2010 9:08 AM To: Bachman, William Subject: RE: [NMusers] negative iteration numbers in .ext files
Bill, Pages 33 and 34, Introduction to NONMEM 7 (August 11, 2009) provide the explanation regarding negative iteration values. Bob plans to add a table of contents for a future release. Tom -----Original Message----- From: [email protected] [mailto:[email protected]] On Behalf Of Bachman, William Sent: Friday, April 16, 2010 8:09 AM To: [email protected]; [email protected] Subject: RE: [NMusers] negative iteration numbers in .ext files Andreas, you are not alone. We all have negative iterations. They are just flags for the final parameter estimates (-1000000000) and their standard errors (-1000000001) that can be used as parsing tags for other programs. I could not quickly find where this is documented. Bill -----Original Message----- From: [email protected] [mailto:[email protected]] On Behalf Of [email protected] Sent: Friday, April 16, 2010 5:30 AM To: [email protected] Subject: [NMusers] negative iteration numbers in .ext files Does anyone else have the 'feature' of negative iteration numbers in the .ext file that nonmem writes? Mostly the values are similar or identical to the preceding lines but not always (see example below). I am using nonmem 7.1.2 with gfortran 4.5.0, installed with nmqual 7.1.0 on Windows XP. Thanks for any clues. Andreas TABLE NO. 1: First Order Conditional Estimation with Interact ITERATION THETA1 THETA2 THETA3 THETA4 ....OMEGA(10,10) OBJ 0 2.70000E+02 7.00000E+01 7.00000E+00 3.00000E+00 0.00000E+00 17903.085422267555 10 2.62990E+02 4.41321E+01 7.48823E+00 4.16453E+00 0.00000E+00 17596.998988682855 20 2.30575E+02 7.98655E+01 7.36614E+00 1.19184E+01 0.00000E+00 17573.820822902107 30 2.31353E+02 7.94068E+01 7.36395E+00 1.17636E+01 0.00000E+00 17573.797569595510 40 2.31992E+02 7.88078E+01 7.38680E+00 1.16398E+01 0.00000E+00 17573.754599870816 -1000000000 2.31992E+02 7.88078E+01 7.38680E+00 1.16398E+01 0.00000E+00 17573.754599870816 -1000000001 1.27442E+01 1.15823E+01 1.56697E-01 3.27570E+00 1.00000E+10 0.0000000000000000 The information of this email and in any file transmitted with it is strictly confidential and may be legally privileged. It is intended solely for the addressee. If you are not the intended recipient, any copying, distribution or any other use of this email is prohibited and may be unlawful. In such case, you should please notify the sender immediately and destroy this email. The content of this email is not legally binding unless confirmed by letter. Any views expressed in this message are those of the individual sender, except where the message states otherwise and the sender is authorised to state them to be the views of the sender's company. For further information about Actelion please see our website at http://www.actelion.com ICON plc made the following annotations. ------------------------------------------------------------------------ ------ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835 ICON plc made the following annotations. ------------------------------------------------------------------------------ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835
