Databases

Indications

Compound classes

#trials/ # subjects

RA

Rheumatoid arthritis (RA)

Psoriatic arthritis (PsA) or psoriasis (Ps)

All biologics

Newer synthetic DMARDS

Older drugs as active control

94/ 38,460

Neuropathic Pain

Diabetic neuropathy (DPN)

Post herpetic neuralgia (PHN)

Fibromyalgia

All drugs approved or in development

Older drugs as active control

57*/ 17,390*

Osteoporosis

Prevention and treatment of post

menopausal osteoporosis

Bisphosphonates, HRT, SERMs, calcitonin,

PTH

Newer therapies

78*/ 108,000*

HCV

Chronic HCV

Long-acting pegylated  interferons

Newer small molecules

Older drugs as active control

128/ 35,728

Depression

  Major depression

 All approved treatments

 All registration trials (minimize impact of

publication bias)

75/17,667

Schizophrenia

Schizophrenia monotherapy, and

add-on therapy for refractory

Schizophrenia

Typical & atypical anti-psychotics

Augmentation treatments

114/26203

Alzheimer's

Alzheimer's

Geriatric Cognitive Impairment

NMDA Antagonists

AChE Inhibitors

Abeta Drugs & others in development

155/TBD

Dyslipidemia

Dyslipidemia, progression of

atherosclerosis, prevention of CV

events

Statins, fibrates, cholesterol absorption

inhibitors, Niacin

Over 500/TBD










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