Ayyappa
Most likely, this is a coding error, so it would help if you post the
code of your model.
Leonid
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Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566
On 8/16/2010 6:09 PM, Ayyappa Chaturvedula wrote:
Dear All,
I am having a strange issue with my model. I have a dataset after oral
administration and samples are collected on time points 0,1,2,4 and 8
hours at steady state. I fit this data with ADVAN5 to a 2-comp model. I
am getting volume of peripheral compartment estimated as my initial
estimate. Other parameters are not much changing by changing Peripheral
comp. Thinking this is identifiability issue (probably not), I tried a
1-comp model and the fit was worse than 2-comp and OBJFUN also much
higher than 2-comp model. I tried several initial estimates of the
peripheral volume but doing the same thing. I appreciate if anybody
share some of their experience here.
I am giving my initial estimate in this format: $THETA (0,500);POPVP
Regards,
Ayyappa Chaturvedula
