Pharmacokinetic-Pharmacodynamic Scientist/Pharmacometrician AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. But we're more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.
The arena You will work as a Senior Research Scientist/Associate Principal Scientist within the in-vivo section, DMPK, Local Discovery at AstraZeneca R&D Södertälje. The role In the drug discovery and early clinical development phase, compounds are screened, optimized and selected for testing in humans. You can play an important role in this process by establishing pharmacokinetic-pharmacodynamic (PKPD) relationships in vitro, in vivo and through back and forward translation of clinical data. Actively applying PKPD concepts to planning and coordination of studies as well as analyzing the outcome using PKPD modeling is part of your work. You also will be responsible for gathering and presenting the PKPD results to project teams. Furthermore, you will be working with understanding of the correlation between in-vitro and in-vivo ADME properties and the prediction of human pharmacokinetics. Collaboration with other team members and other researchers within and outside AstraZeneca R&D is key in our drug discovery and early development process, which means that you need to be able to represent the department on scientific meetings and at project presentations. Minimum experience You hold a PhD or equivalent knowledge level within pharmacology, medicine, physiology, bio-engineering, pharmacometrics or related disciplines with relevant experience in pharmacokinetic-pharmacodynamic modelling. * Advanced user of computer programs routinely used in modelling and simulation like WinNonlin, Berkeley Madonna, NONMEM, R. * Have interest in and knowledge of both the mathematical, physiological and pharmacological aspects of modelling and simulation in drug discovery and early development * Are enthusiastic and have good personal communication skills and the drive to interact successfully with colleagues at all levels and disciplines. You need to be precise, ordered and focussed on your work. You should be interested of problem solving. Also, you need to have excellent collaboration skills. You need to have good experience with computer software and you need to be able to express yourself in English, both orally and in written form. Preferred experience/requirements If you have experience in one or more of the following fields such as antibody PKPD, disease modelling, optimal experimental design or systems pharmacology it is an advantage. More information Interviews will be held on September 27. For more information please contact: Sandra Visser (+46 8553 24436). Please apply online: http://www.astrazeneca.se/Career/?itemId=3185699 <http://www.astrazeneca.se/Career/?itemId=3185699> -------------------------------------------------------------------------- Confidentiality Notice: This message is private and may contain confidential and proprietary information. If you have received this message in error, please notify us and remove it from your system and note that you must not copy, distribute or take any action in reliance on it. Any unauthorized use or disclosure of the contents of this message is not permitted and may be unlawful.
