Dears
We have been working in a pk model to prove that a drug can changes its own
kinetics as a function of dose. Standards pharmacokinetics models assume a
linear relationship between dose and plasma concentrations.Till now our results
show clearly a non-linearity between dose and drug-kinetics, using dose as
covariate. But we are interested to include a dynamic covariate like CO, CI
and/or MABP as covariate using differential equation solutions .
Any suggestions, reference papers, ideas
Thanks so much
Olinto
Olinto-Jose Linares-Perdomo, BS in Electrical Engineering, M.S., Ph.D.
Biomedical Informatics Department & Pharmaceutics Department.
University of Utah-USA
Office:(801)-585-5287
Cell: 001-(801)-783-9487
Fax: (801)-581-3467
-------------------------------------
Confidentiality Note: This message is intended for use only by the individual
or entity to which it is addressed and may contain information that is
privileged, confidential, and exempt from disclosure under applicable law. If
the reader of this message is not the intended recipient or the employee or
agent responsible for delivering the message to the intended recipient, you are
hereby notified that any dissemination, distribution or copying of this
communication is strictly prohibited. If you have received this communication
in error, please contact the sender immediately and erase it
