Dear all
I am trying to implement a double peak absorption profile for a compound using NMVI, I am using the following program to model the fact the drug is absorbed into unequal doses each absorbed by a first order process governed by different rate constant and lag times . Do you agree with this model? $PK ;disposition parameters TVCL=THETA(1) CL=TVCL*EXP(ETA(1)) TV=THETA(2) V=TV*EXP(ETA(2)) TVQ=THETA(3) Q=TVQ*EXP(ETA(3)) TV2=THETA(4) V2=TV2*EXP(ETA(4)) KA1=THETA(5) KA2=THETA(6) ALAG1=THETA(7) ;lagtime for 2nd release ALAG2=ALAG1+THETA(8) ;F1 fraction of the dose absorbed through the first process F1=THETA(9) ;F2 fraction of the dose absorbed through the 2nd process F2=1-F1 ;SCALE FACTOR S2=V/1000 K20=CL/V K23=Q/V K32=Q/V2 $DES DADT(1) = -F1*ALAG1*KA1*A(1)-F2*ALAG2*KA2*A(1) DADT(2) = F1*ALAG1*KA1*A(1)+F2*ALAG2*KA2*A(1)+K32*A(3)-K23*A(2)-K20*A(2) DADT(3) = -K32*A(3)+K23*A(2) Virginie GUALANO PhInC DEVELOPMENT -
