Nieves,
I have no idea why you want to do this but if you want to have the same
random number at every time then the simplest and most efficient way to
do this is to create the random number as a data item in your data set.
You can use the rand() function in Excel to generate a pseudo-random
uniform sample at each time. It is a waste of computer cycles to have to
keep calling the random number generator for every record if you want
the same random number value.
On the other hand if you want a different random number every time you
reach a particular record then that is a more complicated matter. I
expect it can be done with a verbatim code call but I do not know how.
Perhaps you can use?
" CALL RANDOM(2,R)
It would be interesting to know why you want the random number when you
are not doing simulation.
Best wishes,
Nick
On 14/03/2011 10:32 a.m., Nieves Vélez de Mendizabal wrote:
Dear NONMEM Users,
I'm developing a model with NONMEM6|7. In this model, I need to
generate a random number at every time step. The problem is that the
use of the function "CALL RANDOM (2,R)" is supposed to be only for
simulation, isn't it?
Thus, is it possible to generate a random number at every time step
with NONMEM? Does anybody know how?
This is part of the code that does not work (it's not working because
the condition ICALL.EQ.4 never happens and for that it's not getting
into the "if", but on the other hand, in order to use the function
RANDOM(2,R), such function requires ICALL.EQ.4):
...
$SUBS ADVAN6 TOL=5
$MODEL
...
$PK
...
IF (ICALL.EQ.4) THEN
CALL RANDOM (2,R) ;Rand number in[0,1[
T=1-R
...
ENDIF
$DES
...
$ERROR
...
$ESTIMATION MAXEVAL=0 NUMERICAL METHOD=COND LAPLACE LIKE CENTERING
PRINT=2 MSFO=msfo3
Thank you!
Nieves
--
--------------------------------
Nieves Velez de Mendizabal, Ph.D
Departamento de Farmacia y Tecnología Farmacéutica
Facultad de Farmacia
Universidad de Navarra
Phone: (+34) 658 732 851
Phone: (+34) 948 255 400 ext. 5827
[email protected]
--------------------------------
--
Nick Holford, Professor Clinical Pharmacology
Dept Pharmacology& Clinical Pharmacology
University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand
tel:+64(9)923-6730 fax:+64(9)373-7090 mobile:+64(21)46 23 53
email: [email protected]
http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford
