Dear nmusers
[transit compartment model in PK/PD modeling] I was implementing transit model for PK/PD model of ARB(angiotensin II receptor blocker) effect. I had two questions for this model. 1) How can I use the method of Savic(to account for delay in absorption; Savic et al, 2007) to account for delay in the effect? 2) If the above mentioned method is not available for the effect model and the number of compartment should be manually optimized, what is the best method to determine optimal number of transit compartment? Sincerely Jongtae Lee M.D. Resident Clinical pharmacology Seoul St. Mary's hospital 505 Banpo-Dong, Seocho-Gu, Seoul 137-701, Korea TEL: +82-2-2258-7882 FAX: +82-2-2258-7876 [email protected]
