Hi Al I presume by limited sampling design software you are referring to optimal sampling software? There are some historical differences between how the terms limited and optimal sampling are used.
Without specifically trying your problem, I would believe that most optimal design software would be able to handle this type of problem. Indeed most problems that can be coded in NONMEM can probably be run in an optimal design software. It's really just a matter of picking your preference. For instance the Adapt series covers single subject optimal design and programmes like PFIM, PopED, PopDes, WinPOPT, PKStamp handle population problems (at the time of writing this I was unable to locate PKStamp via google). There is a population optimal design listserver: [email protected]<mailto:[email protected]> which specifically handles questions of this nature (you need to join up at http://lists.otago.ac.nz/listinfo/popdesign to use it). I am not aware of any limited sampling software. Regards Steve -- Professor Stephen Duffull Chair of Clinical Pharmacy School of Pharmacy University of Otago PO Box 56 Dunedin New Zealand E: [email protected]<mailto:[email protected]> P: +64 3 479 5044 F: +64 3 479 7034 W: http://pharmacy.otago.ac.nz/profiles/stephenduffull Design software: www.winpopt.com<http://www.winpopt.com> From: [email protected] [mailto:[email protected]] On Behalf Of Berg, Alexander K., Pharm.D., Ph.D. Sent: Saturday, 7 May 2011 10:51 a.m. To: [email protected] Subject: [NMusers] Limited Sampling with Enterohepatic Recirculation Good afternoon - I am curious if anyone could tell me if any of the limited sampling design software are able to handle enterohepatic recirculation models. Specifically, I have a model that is coded as follows: $PK IF(AMT.GT.0)PODO=AMT MU_1=LOG(THETA(1)) KA1=EXP(MU_1+ETA(1)) BIO=1 ; bioavailability = 1 for tablet MU_2=LOG(THETA(2)) MTT=EXP(MU_2+ETA(2)) MU_3=LOG(THETA(3)) N=EXP(MU_3+ETA(3)) F1=0 TVK20=THETA(4) K20=TVK20*EXP(ETA(4)) TVV=THETA(5) V=TVV*EXP(ETA(5)) TVK23=THETA(6) K23=TVK23*EXP(ETA(6)) TVK32=THETA(7) K32=TVK32*EXP(ETA(7)) TVK35=THETA(8) K35=TVK35*EXP(ETA(8)) TVK53=THETA(9) K53=TVK53*EXP(ETA(9)) TVK24=THETA(10) K24=TVK24*EXP(ETA(10)) TVK41=THETA(11) K41=TVK41*EXP(ETA(11)) TVMTIME1=THETA(12) MTIME(1)=TVMTIME1*EXP(ETA(12)) TVDUR=THETA(13) MTIME(2)=MTIME(1)+TVDUR*EXP(ETA(13)) S2=V S3=V S6=V K12=KA1 KTR=(N+1)/MTT LNFAC=LOG(2.5066)+(N+0.5)*LOG(N)-N MU_4=LOG(TVK20) MU_5=LOG(TVV) MU_6=LOG(TVK23) MU_7=LOG(TVK32) MU_8=LOG(TVK35) MU_9=LOG(TVK53) MU_10=LOG(TVK24) MU_11=LOG(TVK41) MU_12=LOG(TVMTIME1) MU_13=LOG(TVDUR) $DES DL=1/100000 FLAG=MPAST(1)-MPAST(2) DADT(1)=EXP(LOG(BIO*PODO+DL)+LOG(KTR+DL)+N*LOG(KTR*T+DL)-KTR*T-LNFAC)-K12*A(1)+K41*A(4)*FLAG DADT(2)=K12*A(1)-(K23+K20+K24)*A(2)+K32*A(3) DADT(3)=K23*A(2)-(K35+K32)*A(3)+K53*A(5) DADT(4)=K24*A(2)-K41*A(4)*FLAG DADT(5)=K35*A(3)-K53*A(5) Since I am using the MPAST coding in NONMEM to account for the EHR, is there any way that I can use this type of coding (or a variation thereof) with any of the optimal design software programs that are available? If not, I was curious if anyone has any experience with designing limited sampling strategies in the context of enterohepatic recirculation and could possibly give me some advice. Thanks in advance - Al Alexander Berg, Ph.D./Pharm.D. Clinical Pharmacology Fellow Mayo Clinic - Rochester [email protected] 507-284-4303
