APPLYING PREDICTIVE SCIENCE AT ASTRAZENECA: OPPORTUNITIES IN MODELLING & SIMULATION JOBS
The new R&D strategy at AstraZeneca includes a substantial increase in investment in Predictive Sciences - so we can tackle illness and disease with even more effective drugs. So from cancer to diabetes and beyond, we will apply the model-based approach to the whole drug development process. To realise this, we are making significant investments in people. If you're already in a modelling and simulation role, or have a background in bio-mathematical modelling, quantitative systems biology, applied mathematics, engineering, pharmacokinetics or statistics, then you may have the skills to make a big contribution to the development of important new medicines. Within the Clinical Science Department we have currently vacancies for the following three roles: Therapetic Area Pharmacometrics Expert (ref SWE000000NR, location Gothenburg/Mölndal, Sweden or Wilmington, US), Section Director Pharmacometrics (ref SWE000000NS , location Gothenburg/Mölndal, Sweden or Wilmington, US) and Pharmacometrician/Senior Pharmacometrician (ref SWE000000NS, location: all sites). The role descriptions together with contact details are given below and at http://jobs.astrazeneca.com/ Welcome to apply for any of the positions at http://www.astrazeneca.se/Career/Vacancies?itemId=3184958&nav=yes <http://www.astrazeneca.se/Career/Vacancies?itemId=3184958&nav=yes> ! Include job number as search string. Closing date is July 10, 2011. ------------------------------------------------------------------------------------------------------------------------------ THERAPEUTIC AREA PHARMACOMETRICS EXPERT, CV/GI or R&I Job number: SWE000000NR Location: Mölndal/Gothenburg, Sweden or Wilmington, US The Therapeutic Area Pharmacometrics Expert position is a strategic and scientific job within Clinical Pharmacology Science, accountable for the modelling work being performed within a specific Therapeutic Area (TA). The current openings are within Cardiovascular/Gastrointestinal (CV/GI) and Respiratory/Inflammation (R&I) TAs. This person will also apply disease modelling to clinical program design with a clear sight of models available internally and externally. The incumbent will provide the strategic direction to enable the Director of Pharmacometrics to deploy PM resources to the projects where modelling will have the greatest impact. As a member of the Senior Leadership of Clinical Pharmacology Science, he/she will contribute to the strategic direction and business effectiveness of the department. He/she may be responsible for one or for multiple global drug projects within the same indication / therapeutic area. He/she leads large and/or complex projects, interacts with regulatory authorities and key opinion leaders, provides coaching and mentoring to other pharmacometricians providing support to projects in the TA, and is accountable for the pharmacometric soundness of the modelling and simulation efforts for the assigned projects. He/she is expected to complete these tasks with very minimal supervision, appropriately and pro-actively seeking line management intervention where needed to ensure successful outcome, e.g. with respect to project resource requirements or key strategic functional issues. Minimum experience For the Therapeutic Area Pharmacometric Expert (TAPE) role, the applicant has preferably a doctorate degree with demonstrated expertise in pharmacometrics, with substantial knowledge about contemporary software and tools within the field of M&S and strong quantitative skills (e.g. experience in mechanistic modelling/systems pharmacology, quantitative translational scaling, literature meta-analyses, population modelling). The TAPE's experience may have been gained in a variety of disciplines including pharmacology, pharmaceutical sciences, biostatistics, medicine, physiology, or engineering. Significant experience should have been gained by working in drug development in the pharmaceutical industry. More information For more information about the positions please contact Marie Sandström, Director Clinical Pharmacometrics +46 8 553 27835 ([email protected]). ----------------------------------------------------------------------------------------------------------------------- SECTION DIRECTOR CLINICAL PHARMACOMETRICS Job number: SWE000000NS Location: Gothenburg/Mölndal, Sweden and Wilmington, US This is a role within our Clinical Pharmacology Science group which is involved in candidate drug (CD) selection and in all clinical phases of the product development including registration and commercialization. The Section Director Clinical Pharmacometrics combines line management with the scientific role of Sr Clinical Pharmacometrician with responsibilities for development of pharmacostatistical models including disease models, exposure response models, biomarker - efficacy models etc. The Sr Clinical Pharmacometrician is accountable for developing MBDD plans for assigned projects. As a Section Director, he/she will be responsible for all line management accountabilities for up to 8-12 Pharmacometrician as direct reports and will work together with Section Director colleagues, the global Director Clinical Pharmacometrics and Therapeutic Area Pharmacometrics Experts to ensure recruitment, training, development and deployment of Pharmacometricians, to optimize project delivery and to support implementation of Model Based Drug Development within AstraZeneca. Minimum experience For the Section Director Clinical Pharmacometrics role, a doctorate degree with demonstrated expertise in pharmacometrics and strong quantitative skills (e.g. experience in mechanistic modelling/systems pharmacology, quantitative translational scaling, literature meta-analyses, population modelling) is required. The pharmacometrics experience may have been gained in a variety disciplines including pharmacology, pharmaceutical sciences, biostatistics, medicine, mathematics, physiology, or engineering. At least 5 years of his/her experience should have been gained by working in drug development in the pharmaceutical industry. The applicant should preferably have experience in line management, training of others and/or scientific supervision. More information For more information about the positions please contact Marie Sandström, Director Clinical Pharmacometrics +46 8 553 27835 ([email protected]). ------------------------------------------------------------------------------------------------------------------------------ CLINICAL PHARMACOMETRICIAN/SENIOR CLINICAL PHARMACOMETRICIAN Job number SWE000000NT Location: Various Clinical Pharmacometrician (PM) and Senior Clinical Pharmacometrician (Sr PM) are scientific roles within our Clinical Science group which is involved in candidate drug (CD) selection and in all clinical phases of the product development including registration and commercialization. We are looking for several individuals to fill the roles in Sweden, UK and the US. The PM/Sr PM works closely together with other modelling skills (such as preclinical PKPD scientists, statistical modelers etc ) to develop MBDD plans for disease area related as well as compound related modelling. The PM/Sr PM develops pharmacostatistical models including disease models, exposure response models, biomarker - efficacy models etc. The PM/Sr. PM works as a partner in multi-disciplinary development teams by providing MBDD expertise. Effective collaborations with physicians, DMPK PK/PD scientists, statisticians, clinical pharmacologists and regulatory affairs experts are of key importance. The Sr PM will, together with statisticians, have the overall accountability for the MBDD plan. We will also look to these individuals to collaborate externally by publishing their work, building relationships with academic institutions and building their expertise by networking with individuals in the pharmacometrics field. Individuals in the senior role will also be called upon to coach less senior staff in their modelling work. Minimum experience For the Sr. Pharmacometrician role, a doctorate degree with demonstrated expertise in pharmacometrics and strong quantitative skills (e.g. experience in mechanistic modelling/systems pharmacology, quantitative translational scaling, literature meta-analyses, population modelling) is required. For the PM role, candidates will have a doctorate degree (preferred) but a Master's degree and other relevant academic training in pharmacometrics and quantitative sciences is acceptable. The PM´s/Sr. PM's experience may have been gained in a variety disciplines including pharmacology, pharmaceutical sciences, biostatistics, medicine, mathematics, physiology, or engineering. At least 5 years of the Sr PM´s experience should have been gained by working in drug development in the pharmaceutical industry. More information For more information about the positions please contact Marie Sandström, Director Clinical Pharmacometrics +46 8 553 27835 ([email protected]) or for location in Sweden Section Director Clinical Pharmacometrics Per-Henrik Zingmark +46 8 553 23942 ([email protected]), location in UK Section Director Clinical Pharmacometrics Marc-Antoine Fabre +44 1509 644253 ([email protected]) and for location in the US Section Director Clinical Pharmacometrics Bruce Birmingham +1 302 886 7527 ([email protected]) Marie Sandström On behalf of Clinical Pharmacology Sciences Leadership Team ______________________________________________ Marie Sandström, PhD Director Clinical Pharmacometrics AstraZeneca R&D +46 8 553 27835 +46 708 467727 -------------------------------------------------------------------------- AstraZeneca UK Limited is a company incorporated in England and Wales with registered number: 03674842 and a registered office at 2 Kingdom Street, London, W2 6BD. 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