Have a look at those two references:
J Pharmacokinet Pharmacodyn. 2009 Oct;36(5):381-405. Epub 2009 Aug 21.
Methods of utilizing baseline values for indirect response models. Woo
S, Pawaskar D, Jusko WJ.
J Pharmacokinet Pharmacodyn. 2008 Jun;35(3):269-83. Epub 2008 Apr 30.
Approaches to handling pharmacodynamic baseline responses. Dansirikul C,
Silber HE, Karlsson MO.
Vinogradova Svetlana wrote:
Dear NONMEM users,
I'm analyzing a dataset of 4 patients, there are 2 types of observations for each patient
- vehicle (say baseline) and dose (treatment). We want to analyze our dataset in terms of
(treatment-baseline). So I've modified my dataset, and now I have only one
"column" of observations for each patient: DV= (treatment-baseline). But now I
have some problems because I have some negitive values in DV column. In case of some
models it results in problems, for example:
TEFF = TBAS + (TSLP*CP)**TALP
so TSLP should be positive but it's not that right...
Maybe there are some common methods to deal with this case?
Thanks a lot,
Svetlana
