Hi, NMusers;
I have a data set with steady state multiple dose administration at every 12
hours. However, many of the dosing intervals are not exactly 12 hours, but have
some delay. Below is an example of my data set (one TIME point is 60.9 instead
of 60). I am using SS=1 and II=12 to describe the multiple SS doses. But for
those time points with small delay, should I just ignore the time different and
still use II=12? Is this going to affect my result? Or should something else to
put in with SS and II? Thank you very much for your help.
ID,AMT,TIME,DV,MDV,SS,II
3,739,0.00,.,1,1,12
3,739,12.00,.,1,1,12
3,739,24.00,.,1,1,12
3,739,36.00,.,1,1,12
3,739,48.00,.,1,?,?
3,739,60.90,.,1,?,?
3,739,81.00,.,1,1,12
3,739,93.00,.,1,1,12
3,739,105.00,.,1,1,12
3,739,117.00,.,1,1,12
3,739,129.00,.,1,1,12
3,739,141.00,.,1,1,12
3,739,153.00,.,1,1,12
3,739,165.00,.,1,1,12
3,.,176.93,1.08,0,.,.
3,739,177.08,.,1,0,0
3,.,177.45,2.7,0,.,.
3,.,177.75,3.26,0,.,.
3,.,178.10,1.52,0,.,.
3,.,178.57,1.52,0,.,.
Min
