Thanks Jerone, using OMEGA of 0.01 instead of 0.07 (I did not try REALLY small OMEGAs) did help. Sven |------------> | Von: | |------------> >--------------------------------------------------------------------------------------------------------------------------------------------------| |"Elassaiss - Schaap, J. (Jeroen)" <[email protected]> | >--------------------------------------------------------------------------------------------------------------------------------------------------| |------------> | An: | |------------> >--------------------------------------------------------------------------------------------------------------------------------------------------| |Sven Mensing <[email protected]> | >--------------------------------------------------------------------------------------------------------------------------------------------------| |------------> | Datum: | |------------> >--------------------------------------------------------------------------------------------------------------------------------------------------| |08.12.2011 10:43 | >--------------------------------------------------------------------------------------------------------------------------------------------------| |------------> | Betreff: | |------------> >--------------------------------------------------------------------------------------------------------------------------------------------------| |RE: [NMusers] PRED EXIT in first ITERATION causes METHOD=COND to crash not ITS | >--------------------------------------------------------------------------------------------------------------------------------------------------| Hi Sven, Have you tried to run a small number of ITS evals before starting with FOCE? i.e. first an $EST line with ITS, than an $EST line with FOCE. Alternatively, you could try to start with (1) improved initial estimates or (2) with very small inits for $OMEGA which should minimize the chance of hitting your exit boundaries during the first step. Best regards, Jeroen J. Elassaiss-Schaap Scientist PK/PD MSD PO Box 20, 5340 BH Oss, Netherlands Phone: + 31 412 66 9320 Fax: + 31 412 66 2506 e-mail: [email protected] From: [email protected] [mailto:[email protected]] On Behalf Of Sven Mensing Sent: Thursday, December 08, 2011 10:06 To: [email protected] Subject: [NMusers] PRED EXIT in first ITERATION causes METHOD=COND to crash not ITS Hello, can someone help me in how to run a rather complex PD model using CONDitional estimation. The model produces errors during ETA search which are very cumbersome to fetch, thus these errors are likely to persist. Since COND does not have a problem with EXIT codes once the first (two?) evaluation steps have been performed, I was wondering whether somebody knows some kind of work-around for this. E.g. ITS is not crashing due to initial ETA errors. Thanks Sven Sven Mensing, PhD Abbott GmbH & Co. KG phone: +49 (0)621 589 Assistant Director, Knollstraße 50 1535 Principal Research 67061 Ludwigshafen fax: +49 (0)621 589 Statistician Germany 1925 Pharmacometrics [email protected] Sitz der Gesellschaft: Wiesbaden, Amtsgericht Wiesbaden HRA 4888 Persönlich haftende Gesellschafterin: Abbott Management GmbH Sitz der Gesellschaft: Wiesbaden, Amtsgericht Wiesbaden HRB 12889 Geschäftsführer: Dr. Friedrich Richter, Alexander Würfel, Luc Ruysen, Matthias Däschner Vorsitzender des Aufsichtsrates: Brian Blaser Disclaimer Der Inhalt dieser Nachricht ist vertraulich, kann gesetzlichen Bestimmungen unterliegen, kann vertrauliche Informationen beinhalten und ist nur für den direkten Empfänger bestimmt. Sie ist Eigentum von Abbott Laboratories bzw. der betreffenden Niederlassung. 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