Re: [NMusers] How to incorporate sampling sites as a covariate?

[Paul Hutson]

Title: Paul R

Dear Huali: It depends.  What are you trying to do with the two data sets? One of the classic articles on this subject is by Dr Chiou: The phenomenon and rationale of marked dependence of drug concentration on blood sampling site. Implications in pharmacokinetics, pharmacodynamics, toxicology and therapeutics (Part I). Chiou WL. Clin Pharmacokinet. 1989 Sep;17(3):175-99. Paul On 1/5/2012 1:34 PM, Wu, Huali wrote: Dear NMusers:   I have a question regarding covariates in pop PK analysis. Has anyone used sampling sites from subjects as a covariate for PK parameters? In my dataset, each subject had samples from carotid arterial and jugular vein. And the PK profiles from different sites appeared differently. I was wondering if it is possible to incorporate sampling sites as a covariate.   Thank you very much for any suggestions!   Best regards,   Huali   -- Paul R. Hutson, Pharm.D. Associate Professor UW School of Pharmacy 777 Highland Avenue Madison WI 53705-2222 Tel  608.263.2496 Fax 608.265.5421 Pager 608.265.7000, p7856