Dear Sherwin,
Since you have specified IPRED=ATOT (and ATOT=A1+A2), NONMEM is disregarding
the CMT value you have specified on the observation record when calculating
IPRED, i.e. you can set CMT to any value.
Best regards,
Elisabet
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Elisabet Nielsen, PhD
The Pharmacometrics group
Department of Pharmaceutical Biosciences
Uppsala University
-----Original Message-----
From: [email protected] [mailto:[email protected]] On
Behalf Of Sherwin K Sy
Sent: Friday, January 06, 2012 10:59 PM
To: [email protected]
Subject: [NMusers] How to set CMT value for 2-compartment bacterial model
Dear NONMEM users,
I want to set-up a bacterial model consisting of susceptible (S) and
resting phases (R). I use Advan9 in NONMEM for the subroutine. With
Advan9, one has to declare compartments.
My experimental bacterial counts belong to both S and R (i.e. sum of S
and R). And the compartments are such that:
CA=(A(3)) ; compartment for drug
DRUG=EMAX*(CA)/(EC50+(CA)) ; relationship for drug using an Emax model
DADT(1)=K1*A(1)-(K2+DRUG)*A(1)-KSR*A(1)
DADT(2)=KSR*A(1)-K2*A(2)
DADT(3)=KDEG*A(3)
A1=A(1) ; S
A2=A(2) ; R
ATOT=A1+A2 ; N=S+R
A3=A(3) ; Drug Concentration
IPRED = ATOT
I'm wondering as to how or what to set-up for the compartment value
CMT in the input file whenever I have bacterial count observations. I
understand that the CMT for the initial drug concentration will be set
to 3 since drug belongs to compartment 3.
Thank you in advance for your help.
Best regards,
Sherwin Sy
