Dear Pavel, Yes there is, one was published online just recently: Lacroix BD, Friberg LE, Karlsson MO. Evaluation of IPPSE, an alternative method for sequential population PKPD analysis. J Pharmacokinet Pharmacodyn. 2012 Jan 21. In addition to presenting the 2 methods you're referring to, fixing population PK parameters or conditioning on individual PK parameters, it includes a comparison with the simultaneous PKPD fit and introduces an approach accounting for uncertainty in the PK parameters.
Best regards, Elodie -- Elodie L Plan, Pharm.D, Ph.D Metrum Research Group, LLC 2 Tunxis Road, Suite 112 Tariffville, CT 06081 *(860) 560-3770* *(860) 735-7043* On 1 February 2012 11:15, <[email protected]> wrote: > Hello NONMEM Team, > > We usually try to separate PK and PD models and the reasons are > obvious. There are different ways to separate the models. Are there any > good references which show advantages and disadvantages of fixing > population paramterers in the PD model ann allowing the model to estimate > individual PK parameters vs. fixing both population and individual PK > parameters? > > Thanks! > > Pavel >
