The only way that I know is to use SD=SQRT(IPRED**2*THETA(10)**2+THETA(11)**2) Y=IPRED+SD*EPS(1)
RES=DV-IPRED IWRES = RES/SD ; same as EPS(1) $SIGMA 1 FIX Leonid -------------------------------------- Leonid Gibiansky, Ph.D. President, QuantPharm LLC web: www.quantpharm.com e-mail: LGibiansky at quantpharm.com tel: (301) 767 5566 On 2/3/2012 3:21 PM, Dodds, Mike wrote:
All, Is there a way to recover epsilons after an $EST step? The difference between DV and IPRED is epsilon for a simple additive error model. However, with a mixed proportional and additive error model, I can’t see a way to separate the two epsilon contributions to DV-IPRED. $TABLE EPS(1) after an $EST step provides a column of zeros, and the NONMEM manual indicates this is the expected behavior. Warm Regards, Mike Dodds
