The following is a description and complete output listing of an installation of MinGW64 bit gfortran and NONMEM 7.2.0 on Windows 7 64-bit (Home Premium with Service Pack 1).
1. The first step was to uninstall and/or disable any 32-bit gfortran or g95 implementations. In the test case, 32-bit gfortran was disabled by removing the references to gfortran in the PATH environment variable using Control Panel: references removed from PATH: ;C:\Program Files (x86)\gfortran\libexec\gcc\i586-pc-mingw32\4.6.0;C:\Program Files (x86)\gfortran\bin 2. MinGW64 version 4.6.1 for 64 bit gfortran for Windows was downloaded from http://sourceforge.net/projects/mingw-w64/files/latest/download?source=files The filename was mingw-w64-gcc-4.6.3-runtime-2.0.1-static-ada-20120321.7z. 3. The file was extracted using 7-Zip File Manger obtained from http://www.7-zip.org/download.html creating a directory structure starting with a "mingw-w64-gcc-4.6.3-runtime-2.0.1-static-ada-20120321" directory and containing a "mingw64" directory. 4. A "gfortran" directory was created under the C:\Program Files\ directory. The "mingw64" directory was copied from the "mingw-w64-gcc-4.6.3-runtime-2.0.1-static-ada-20120321" directory to the "C:\Program Files\gfortran\" directory. 5. References were created in the PATH environment variable using Control Panel to the new gfortran similar to the old references to gfortran but referencing the new locations. references added to PATH: ;C:\Program Files\gfortran\mingw64\libexec\gcc\x86_64-w64-mingw32\4.6.3;C:\Program Files\gfortran\mingw64\bin 6. The new gfortran 64-bit implementation was tested in a DOS window by "asking" the version and using a simple compile test specifying a 64-bit executable ("-m64") of gmtest.for (file distributed with NONMEM): c:\>cd \nm72\util C:\nm72\util>gfortran --version GNU Fortran (GCC) 4.6.3 Copyright (C) 2011 Free Software Foundation, Inc. GNU Fortran comes with NO WARRANTY, to the extent permitted by law. You may redistribute copies of GNU Fortran under the terms of the GNU General Public License. For more information about these matters, see the file named COPYING C:\nm72\util>gfortran -m64 gmtest.for C:\nm72\util>a.exe ICON Development Solutions - Tools for Expediting Population Analysis (c) 2009-2011 7. NONMEM 7.2.0 was installed from a DOS window using the correct arguments for gfortran. (When "Changes to License file, resource\SIZES.f90 and other resource files may be made here." was displayed prior to Step 6., a valid nonmem.lic file was copied to the c:\nm72gf64\license\ directory and the installation was then allowed to continue.) ["c:\nm72gf64" was used as the installation directory argument just to differentiate this install from other installs on this system.] C:\Users\Bill>cd \ C:\>d: D:\>SETUP72 d: c:\nm72gf64 gfortran y ar same rec i NONMEM 7.2.0 INSTALLATION UTILITY - Windows/DOS batch file version For instructions, see readme_7.2.0.pdf or readme_7.2.0.txt on the CD SETUP72 d: c:\nm72gf64 gfortran y ar same rec i unzip.exe nonmem72e.zip nonmem72r.zip CD-ROM drive is d: NONMEM 7.2.0 directory is c:\nm72gf64 Command for FORTRAN compiles is gfortran Optimization for Fortran compiles is y Command to build NONMEM archive is ar Sizes is same Recompile is rec All binaries will be recompiled Interactive is i Unzip is unzip.exe Encrypted source file is nonmem72e.zip Unencrypted file is nonmem72r.zip To learn how to override the defaults, enter SETUP72 help Continue (y/n)? [y] The directory c:\nm72gf64 does not exist. Step 1. Creating c:\nm72gf64 Step 1a. Copy files from d: to c:\nm72gf64 1 file(s) copied. 1 file(s) copied. 1 file(s) copied. 1 file(s) copied. 1 file(s) copied. 1 file(s) copied. 1 file(s) copied. 1 file(s) copied. 1 file(s) copied. 1 file(s) copied. 1 file(s) copied. 1 file(s) copied. 1 file(s) copied. 1 file(s) copied. 1 file(s) copied. Step 1b. Copy files from d:\NONMEM_7.2.0 to c:\nm72gf64 Installing NONMEM 7.2.0 (Enter Ctrl-C to interrupt) ... Step 2a. Make sub-directories of c:\nm72gf64 Extract rest of files Using resource\SIZES.f90 Choosing platform-dependent files ... Will use install_Win.exe Will use util\finish_win_gfortran.bat ===Checking compiler start compile/link end compile/link === Copying NONMEM license file nonmem.lic to c:\nm72gf64\license\nonmem.lic Warning: the license may be expired or may expire soon. When this happens, NONMEM runs will fail. If you have a new license file from IDS, you may stop, replace it and restart SETUP72. Otherwise, allow NONMEM installation to finish at this time. Obtain a new license file from IDS ([email protected]) as soon as possible and replace c:\nm72gf64\license\nonmem.lic Changes to License file, resource\SIZES.f90 and other resource files may be made here. Continue (y/n)? [y] Step 6. Compile resource files Compile of resource files was successful. ar: creating resource.a resource directory has been compiled Continue (y/n)? [y] Step 9. Compile all remaining source files This will take a long time. See file c:\nm72gf64\progress.txt for compiler progress Step 10. Build NONMEM archive nm\nonmem.a Step 13. Create shell script util\nmfe72 Step 14. Create directory run run contains the following files: nmfe72.bat CONTROL3 CONTROL5 DATA3 THEOPP REPORT5IDS.txt run contains additional files Installation of NONMEM 7.2.0 is finished. For future reference, the command has been saved in file SETUP.TXT Please review c:\nm72gf64\compilemsgs.txt c:\nm72gf64\finishmsgs.txt Ignore warnings. Report error messages. Do you want to install help and html files and Users Guides? Continue (y/n)? [y] Help and html files and Users Guides will be installed. Step 15. Install NONMEM Users Guide files in c:\nm72gf64\guides Unzipping guides.zip... To use the NONMEM Users Guides, open pdf files in c:\nm72gf64\guides using Adobe Reader. Step 16. Install On-line help files in c:\nm72gf64\help Unzipping help.zip... "Installing On-Line Help Tools ..." For online help, enter (e.g.) cd c:\nm72gf64\help nmhelp advan2 Step 17. Install HTML files in c:\nm72gf64\html (this may take a while) ... Unzipping html.zip... For online help HTML files, open c:\nm72gf64\html\index.htm in web browser Do you want to test the installation? Continue (y/n)? [y] Testing the installation. Commands are cd c:\nm72gf64\run nmfe72 CONTROL5 REPORT5.txt -prdefault If the run is successful, file REPORT5.txt will be created. doing nmtran WARNINGS AND ERRORS (IF ANY) FOR PROBLEM 1 (WARNING 2) NM-TRAN INFERS THAT THE DATA ARE POPULATION. (WARNING 43) THE $PK BLOCK REQUESTS "CALL ONCE PER INDIVIDUAL RECORD", BUT DATA ITEMS ARE USED IN THE $PK BLOCK. VALUES OF THESE DATA ITEMS SUBSEQUENT TO THOSE FROM THE FIRST EVENT RECORD WILL BE IGNORED. IF THIS IS NOT APPROPRIATE, THE CALL DATA ITEM CAN BE USED TO OBTAIN ADDITIONAL CALLS, OR $PK'S CALLING PROTOCOL SHOULD BE CHANGED. CREATING MUMODEL ROUTINE... 1 file(s) copied. Finished compiling fsubs Completed call to gfcompile.bat Starting nonmem execution ... License Registered to: IDS NONMEM 7 TEAM Expiration Date: 2 JUN 2013 Current Date: 9 MAY 2012 Days until program expires :393 First Order MONITORING OF SEARCH: 0ITERATION NO.: 0 OBJECTIVE VALUE: 110.244034784025 NO. OF FUNC. EVALS.: 6 CUMULATIVE NO. OF FUNC. EVALS.: 6 NPARAMETR: 3.0000E+00 8.0000E-02 4.0000E-02 6.0000E+00 5.0000E-03 3.0000E-01 2.0000E-04 6.0000E-03 4.0000E-01 4.0000E-01 PARAMETER: 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 1.0000E-01 GRADIENT: 1.4640E+01 -1.6691E+01 5.6460E+01 -9.4129E+00 -1.1699E+01 1.0623E+01 -6.3485E-01 -4.7803E+01 -9.6457E+00 5.2414E+00 0ITERATION NO.: 5 OBJECTIVE VALUE: 105.453694506201 NO. OF FUNC. EVALS.: 7 CUMULATIVE NO. OF FUNC. EVALS.: 45 NPARAMETR: 2.8166E+00 8.0433E-02 3.8563E-02 6.6123E+00 9.7862E-03 -3.9509E-02 2.3438E-04 8.1375E-03 4.9657E-01 4.0346E-01 PARAMETER: -5.3055E-02 1.0703E-01 5.7598E-02 1.4858E-01 1.8644E-01 -1.2545E-02 1.5794E-01 1.3452E-01 3.7714E-02 1.0431E-01 GRADIENT: 3.5103E-01 -1.3214E+01 2.8003E+01 1.1115E+00 1.9193E+00 -5.3252E+00 7.1533E-02 -2.2091E+01 -1.4424E+00 8.2329E+00 0ITERATION NO.: 10 OBJECTIVE VALUE: 104.747695561777 NO. OF FUNC. EVALS.: 7 CUMULATIVE NO. OF FUNC. EVALS.: 80 NPARAMETR: 2.7362E+00 7.6935E-02 3.5982E-02 5.7362E+00 1.0840E-03 -2.9208E-01 2.3701E-04 9.4013E-03 5.1805E-01 3.8850E-01 PARAMETER: -1.1928E-01 4.9234E-02 -2.3022E-02 7.7517E-02 2.2174E-02 -9.9574E-02 1.9498E-01 1.4956E-01 -1.7173E-01 8.5414E-02 GRADIENT: -1.3933E+00 -7.4632E+00 9.3144E+00 1.0280E+00 9.6395E-01 -3.1313E+00 1.0212E+00 -5.3784E+00 -2.0828E+00 -9.1477E-01 0ITERATION NO.: 15 OBJECTIVE VALUE: 104.561086502423 NO. OF FUNC. EVALS.: 7 CUMULATIVE NO. OF FUNC. EVALS.: 116 NPARAMETR: 2.7735E+00 7.8097E-02 3.6292E-02 5.5466E+00 5.1735E-03 -1.2911E-01 2.3941E-04 9.0947E-03 5.1461E-01 3.8752E-01 PARAMETER: -8.8567E-02 6.8686E-02 -1.2994E-02 6.0711E-02 1.0762E-01 -4.4762E-02 1.9028E-01 1.4643E-01 -8.4016E-02 8.4157E-02 GRADIENT: 7.7938E-03 5.7189E-03 3.0426E-02 -5.1648E-03 -1.2939E-02 1.4490E-02 7.4602E-04 -2.5227E-02 -3.1443E-03 1.5799E-02 0ITERATION NO.: 19 OBJECTIVE VALUE: 104.561067398632 NO. OF FUNC. EVALS.: 0 CUMULATIVE NO. OF FUNC. EVALS.: 149 NPARAMETR: 2.7739E+00 7.8129E-02 3.6307E-02 5.5498E+00 5.2393E-03 -1.2767E-01 2.3985E-04 9.1064E-03 5.1521E-01 3.8750E-01 PARAMETER: -8.8304E-02 6.9219E-02 -1.2510E-02 6.0998E-02 1.0895E-01 -4.4249E-02 1.9095E-01 1.4652E-01 -8.3269E-02 8.4127E-02 GRADIENT: 1.2144E-04 -1.4882E-04 -6.6303E-06 -7.5745E-05 -1.6157E-05 1.1307E-04 6.4128E-05 1.1193E-04 -1.7655E-05 4.2677E-05 Elapsed estimation time in seconds: 0.28 Elapsed covariance time in seconds: 0.03 You should now compare REPORT5.txt vs. REPORT5IDS.txt Values should be similar. E.g., the following should be identical: find "#OBJV:" REPORT5.txt ---------- REPORT5.TXT #OBJV:******************************************** 104.561 ************************************************** find "#OBJV:" REPORT5IDS.txt ---------- REPORT5IDS.TXT #OBJV:******************************************** 104.561 ************************************************** Above text represents a successful install of NONMEM 7.2.0 with 64-bit gfortran. William J. Bachman, Ph.D. Director, Pharmacometrics R&D Icon Development Solutions 7740 Milestone Parkway Suite 150 Hanover, MD 21076 Office 215-616-8699 [email protected] ICON plc made the following annotations. ------------------------------------------------------------------------------ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835
