Toufigh
It would help to see the plot. One possibility is that the plot is in
the log scale, and you have additive error component that plays larger
role at low concentrations.
Leonid
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Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566
On 5/10/2012 12:49 PM, Toufigh Gordi wrote:
Dear all,
We have performed a VPC using PsN and the results were plotted using
Xpose 4. An interesting feature of the graph is that the outer limits of
the interval do not follow the typical curve smoothly but change with
the observed data. As an example, toward the end of the time interval,
where we have a larger variability in the observations, the lines widen
and capture most of the data. I have difficulties understanding why the
prediction lines behave this way. Any comments?
Toufigh
