Dear users: Some of you who attended the PAGE meeting in Venice last week asked me about the quasi-random parametric expectation maximization method (QRPEM) that was being presented by Bob Leary. This quasi-random sampling method used in QRPEM is the Sobol method, and is available in NONMEM 7.2 for importance sampling or direct sampling. Please read section 1.21., RANMETHOD option (around page 34), in ..\guides\nm720.pdf of your nonmem installation for implementing this sampling method for importance sampling.
Robert J. Bauer, Ph.D. Vice President, Pharmacometrics, R&D ICON Development Solutions 7740 Milestone Parkway Suite 150 Hanover, MD 21076 Tel: (215) 616-6428 Mob: (925) 286-0769 Email: [email protected] Web: www.iconplc.com<http://www.iconplc.com/> ICON plc made the following annotations. ------------------------------------------------------------------------------ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835
