Xiaofeng,
It depends on how you set NSIG (indicate the number of significant digits that population parameters
are to be evaluated at the maximum likelihood).
Further details are provided in Section I.14 Controlling the Precision of the Gradient Evaluation in
the introduction to NONMEM 7.1.2 guide.
Below is the general rule that ICON provides:
While some trial and error may still be required by the user for a given problem, certain general
rules may be considered.
Set SIGL, NSIG, and TOL such that:
SIGL<=TOL
NSIG<=SIGL/3
This section of the guide also provides information about NONMEM 6.
Luann Phillips
Cognigen Corporation
Director, PK/PD
Wang, Xiaofeng wrote:
Hi all,
I wonder if there is an acceptable smallest TOL value for ADVAN6 and
what is it? I searched user guide but did not find the answer. Could
anyone share some information? Thank you.
Xiaofeng
