Dear Khaled, Time varying covariates are be included in a number of ways. This paper by Ulrika Wählby et al. explores this subject in some depth.
Wählby, U., Thomson, A. H., Milligan, P. A., & Karlsson, M. O. (2004). Models for time-varying covariates in population pharmacokinetic-pharmacodynamic analysis. British journal of clinical pharmacology, 58(4), 367-377. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/15373929 Kind regards Dinko Rekic From: [email protected] [mailto:[email protected]] On Behalf Of Khaled Nm Sent: den 30 augusti 2012 14:45 To: [email protected] Subject: [NMusers] Time-varying PK DURING the course of study Dear nmusers, I found it is difficult to account for age varying in PK parameter during the course of the study. Is there any way on how to define icreasing age as a covariate in the NONMEM data file? A short example would be very useful for me. thanks for your help. khaled
