Dear NONMEM users:
Regarding the use of IF ELSE statement in NONMEM, can it be used in the
$DES block in between the differential equations? e.g. in my control
stream attached below in blue, OCCUPANCY was defined by A(3) and A(4),
OCCUPANCY was further used to define INH using IF ELSE statement, and
last, INH was used in the A(5) and A(6) differential equations. Can
NONMEM do this? The error message I received attached below in red is "
RANDOM VARIABLE IS DEFINED IN A NESTED IF STRUCTURE". Berkeley-Madonna
can do such analysis, I just try to see whether it can also work in
NONMEM.
If NONMEM can do this, how can I revise the code?
Thanks for the help!
Best,
Yanke
$DES
DADT(1) =
-CL/V1*A(1)+Q*(A(2)/Vt-A(1)/V1)-kon*(A(1)/V1)*(A(3)/Nbs)+koff*A(4)
DADT(2) = Q*(-A(2)/Vt+A(1)/V1)-CL/Vt*A(2)
DADT(3) = -kL*A(3)-kon*(A(1)/V1)*(A(3)/Nbs)+koff*A(4)+PROD*A(6)*Nbs
DADT(4) = -kAL*A(4)+kon*(A(1)/V1)*(A(3)/Nbs)-koff*A(4)
OCCUPANCY = A(4)/(A(4)+A(3))
IF (OCCUPANCY.LE..3) THEN
INH = 0
ELSEIF (OCCUPANCY.LE..9.AND.OCCUPANCY.GE..3) THEN
INH = OCCUPANCY*5/3-0.5
ELSE
INH = 1
ENDIF
DADT(5) = Stc-kTC*A(5)-(1-INH)*ki*A(3)/Nbs*A(5)/V1
DADT(6) = (1-INH)*ki*A(3)/Nbs*A(5)/V1-kIC*A(6)
AN ERROR WAS FOUND IN THE CONTROL STATEMENTS.
AN ERROR WAS FOUND ON LINE 79 AT THE APPROXIMATE POSITION NOTED:
ENDIF
X
326 RANDOM VARIABLE IS DEFINED IN A NESTED IF STRUCTURE.
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