All, I am implementing the M3 method using NONMEM7.2. My error structure is proportional. I have two questions regarding the control stream shown below.
1. Is the control stream correct for a proportional error model? 2. Each DV has its own LOQ so I cannot give one LOQ value. I was planning to assign a column in my data frame which defines LOQ for each DV. Is this an appropriate approach? Any input/advice would be much appreciated! Thanks, Rebecca Neal Burns, PharmD, PhD Post-Doctoral Scholar, Pharmacometrics Mercer University, Atlanta, GA $ERROR SIG=THETA(4) IPRED=F LOQ=LLOQ DUM=(LOQ-IPRED) CUMD=PHI(DUM) IF (BQL.EQ.0) THEN F_FLAG=0 Y=IPRED*(1+SIG*ERR(1)) ENDIF IF (BQL.EQ.1) THEN F_FLAG=1 Y=CUMD ENDIF $EST METHOD=COND INTER LAPLACIAN $SIGMA 1 FIX
