Yaming
Could you, please, add some more details about the procedure to
determine the time of the event/dose. Is it some numerical integral of
hazard, and when it reaches some value (integral from 0 to T0) then the
dose is given at T0 ? Or you can determine it earlier, say by time T1 <
T0 (where T1 is known in advance)?
Leonid
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Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web: www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel: (301) 767 5566
On 4/3/2013 4:35 PM, Yaming Hang wrote:
Dear NONMEM Users,
I have some questions about how to accomplish the following tasks in
NONMEM, would you kindly share your experience with me or provide some
suggestions? I’m trying to make a simulation that involves dynamic
dosing. Here is the algorithm of simulation: at time 0, a dose is given,
then the time to the first event will be simulated based on a certain
survival function which depends on the drug exposure. Next, conditioning
on that simulated first event time, a second dose will be introduced,
and again time to the second event will be simulated. This will be
repeated until a certain cut off time point.
My specific questions are:
1. since the dosing history will be depending on the simulated event
time, I cannot construct the dosing history in NONMEM data set a prior,
how can this be done?
2. The survival function is a function of the time-varying drug
exposure, therefore I need to inverse an integral which does not have a
closed form (i.e. only expressed in differential equation), how can I do
that?
Your help will be much appreciated!
Yaming Hang
