Simon, Chris I also wish to understand if the Phoenix platform depends on the type of data(eg sparse/rich; single timepoint data). I understand that it is something that can be done in Nonmem. Thank you.
Bernard On 5/1/13, Simon Davis <[email protected]> wrote: > Bernard, I feel I should add to Chris's comments that with the release of > the Phoenix platform, not only did we vastly update and improve the general > WinNonlin environment and provide via the Connect license options to > visually link and manage NONMEM, R, PsN, Xpose etc. in a refreshable and > "template-able" workflow. > > We also implemented NLME in the Phoenix model engine, which gives you a > very convenient GUI to access a range of algorithms, FOCE-ELS, FOCE-LB, > Laplacian, IT2S-EM, and QRPEM, as well as set up various Scenarios to assess > covariates etc.; if you will be at PAGE please consider attending one of our > workshops > > Categorical responses with Phoenix NLME 10-11 June, before PAGE, Glasgow, > UK > > Or the free Connect Workshop session on Tuesday afternoon 11 June; > register through the links here if you're interested; > http://www.pharsight.com/training/training_upcoming.php > > Best regards, > Simon. > > ___________________________________ > [email protected] > Senior Scientific Consultant, Pharsight- A CertaraT Company > > March 2012 Phoenix 6.3, including the new QRPEM algorithm for NLME > released. > January 2013 Reporter object for Phoenix 6.3.1 Connect released. > Get tips and discuss Pharsight products with other users; > www.pharsight.com/extranet > ___________________________________ > http://www.pharsight.com/training/training_upcoming.php > Introduction to Phoenix WinNonlin 25-27 June London, UK > Intermediate PK/PD Modelling with Phoenix WinNonlin 25-28 Jun, Amsterdam, > NL. > Population Modeling Methodology using Phoenix NLME 24-26 September , > Copenhagen, Denmark > > -----Original Message----- > From: [email protected] [mailto:[email protected]] On > Behalf Of Chris Campbell > Sent: Wednesday, April 17, 2013 10:04 AM > To: Bernard Ngara > Cc: nmusers > Subject: RE: [NMusers] NONMEM vs WinNonlin > > Dear Bernard > > NONMEM is command line software for mixed effects modelling, and is commonly > used for multiple subject compartmental modelling. There are eight different > minimization algorithms that you can use, individually or together. You can > usually iterate through model versions, changing initial conditions, > boundary conditions, error structure, etc. to achieve convergence. With this > tool you should be able to estimate some population parameters where sparse > data is available for multiple subjects. Some people prefer to use NONMEM in > conjunction with a third party graphical tool, such as Navigator, that > includes a menu system, visualization utilities and audit tools. > > Pheonix WinNonlin is best known for its non-compartmental modelling, but > also allows single subject compartmental PKPD modelling. For sparse data it > is possible that even the simplest models will not converge. Also note that > you are calculating individual rather than population parameters. Pheonix > NLME has more similar functionality to NONMEM. The Pheonix products are > built around a graphical interface. You may also be interested in looking at > Monolix, which is another mixed effects modelling application. > > Best wishes > > Chris > > > Chris Campbell > > Tel. +44 (0) 1249 705 450 | Mobile. +44 (0) 7929 628 349 > [email protected] | http://www.mango-solutions.com Mango > Solutions, 2 Methuen Park, Chippenham, Wiltshire, SN14 OGB UK > > -----Original Message----- > From: [email protected] [mailto:[email protected]] On > Behalf Of Bernard Ngara > Sent: 12 April 2013 15:49 > To: nmusers > Subject: [NMusers] NONMEM vs WinNonlin > > Dear all > > What are the major similarities and dissimilarities between NONMEM and > WinNonlin in modeling sparse dataset. > > Bernard > > -- > > LEGAL NOTICE > > This message is intended for the use of the named recipient(s) only and may > contain confidential and / or privileged information. If you are not the > intended recipient, please contact the sender and delete this message. 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