Hi István, Because the parameter selected for the reference period will affect the fitting in all periods, I think that the only way to do what you're wanting will be to fit just the reference period and then merge the resulting Ka into your data set and use that instead of fitting it.
A more typical method to use would be to fit a different Ka for each formulation or based on properties of the formulation and use that for your comparison. Thanks, Bill On May 14, 2013, at 5:13 AM, "Németh István (Farma)" <[email protected]<mailto:[email protected]>> wrote: Dear Users, I works on a model describes IVIVC using the approach described by Gaynor et al 2011. The input data come from a cross-over study with a reference period (imediate release). I would like to use the KA bayesian posthoc estimates of this refernece period for all other periods unchanged. My question is, how can I separate this period from the rest ones to ensure that nonmem does not fit this parameter other periods, but the reference? Thanks, István István Németh PhD Developmental Drug Metabolism & Pharmacokinetics Pharmacological and Drug Safety Research Gedeon Richter Plc Tel: 00 36 1 505 7082 Fax: 00 36 1 889 8526
