JO,
Sorry - I didn't understand your earlier request because I had not ever
thought anybody would be interested in those values.IMHO there is almost
no reason to collect this information because the bootstrap parameter
estimates will give you a more reliable variance-covariance matrix of
the estimates.
I will send you separately a replacement nmbs.bat file for use with WFN.
This collects any .cov file that is produced as a single file which will
be in the results directory when nmgosim (or nmbs) finishes. You have to
set the nmraw variable to n or y in order to get this behaviour.
Its up to you to figure out how to extract and use the numbers :-)
Best wishes
Nick
On 14/07/2013 3:32 a.m., NIYI ADEDOKUN wrote:
Hi Nick,
Thanks for your response. I realize the RSEs of the parameter
estimates are included in the .smy file but what I actually need is
the variance-covariance matrix of the estimates. For example, I am
thinking of a table containing the variance of theta(1), variance of
theta(2) as well as the covariance between theta(1) & theta(2). These
values are usually provided in the .lst file following an estimation
run but I would like to have them for all the simulation/estimation
runs with a successful covariance step. Since these estimates are in
the .lst file, there should be some way of outputting them to a table
for further analysis.
Kind regards,
JO
> Date: Sat, 13 Jul 2013 10:06:38 +0200
> From: [email protected]
> To: [email protected]
> Subject: Re: [NMusers] Covariance matrix of parameter estimates
(standard errors)
>
> JO,
>
> *IF* NONMEM is able to complete the covariance step then the relative
> standard errors are included in the WFN nmgosim output file.
>
> You will not find the RSE values if a) you did not include $COV in the
> control stream or b) NONMEM failed in the covariance step.
>
> You can test nmgosim with WFN by running:
>
> nmgosim theopd_gosim theopd_gest 1 5
>
> in the WFN run directory. You will find all the parameters and their
RSE
> values in run\theopd_goest.reg\theopd_goest.smy
>
> Usually there is little interest in calculating these asymptotic RSE
> values because the parametric bootstrap performed by nmgosim gives more
> reliable estimates of the RSE and confidence intervals of parameters.
>
> Nick
>
> On 12/07/2013 10:09 p.m., NIYI ADEDOKUN wrote:
> > Dear All,
> > Is there a simple way to include the standard errors of parameter
> > estimates (as found in the .cov file) in an output table following
> > sequential simulation and estimation in NONMEM? On a related note,
the
> > NMGOSIM command in Wings for NONMEM does not appear to include the
> > .cov file in its output - is there a workaround such that the
standard
> > errors of estimates (e.g. SETHET) can be included in the summary file?
> >
> > Kind regards,
> > JO
> >
> >
>
> --
> Nick Holford, Professor Clinical Pharmacology
> Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A
> University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand
> office:+64(9)923-6730 mobile:NZ +64(21)46 23 53 FR +33(7)85 36 84 99
> email: [email protected]
> http://holford.fmhs.auckland.ac.nz/
>
> Holford NHG. Disease progression and neuroscience. Journal of
Pharmacokinetics and Pharmacodynamics. 2013;40:369-76
http://link.springer.com/article/10.1007/s10928-013-9316-2
> Holford N, Heo Y-A, Anderson B. A pharmacokinetic standard for
babies and adults. J Pharm Sci. 2013:
http://onlinelibrary.wiley.com/doi/10.1002/jps.23574/abstract
> Holford N. A time to event tutorial for pharmacometricians. CPT:PSP.
2013;2: http://www.nature.com/psp/journal/v2/n5/full/psp201318a.html
> Holford NHG. Clinical pharmacology = disease progression + drug
action. British Journal of Clinical Pharmacology. 2013:
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12170/abstract
>
>
--
Nick Holford, Professor Clinical Pharmacology
Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A
University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand
office:+64(9)923-6730 mobile:NZ +64(21)46 23 53 FR +33(7)85 36 84 99
email: [email protected]
http://holford.fmhs.auckland.ac.nz/
Holford NHG. Disease progression and neuroscience. Journal of Pharmacokinetics
and Pharmacodynamics. 2013;40:369-76
http://link.springer.com/article/10.1007/s10928-013-9316-2
Holford N, Heo Y-A, Anderson B. A pharmacokinetic standard for babies and
adults. J Pharm Sci. 2013:
http://onlinelibrary.wiley.com/doi/10.1002/jps.23574/abstract
Holford N. A time to event tutorial for pharmacometricians. CPT:PSP. 2013;2:
http://www.nature.com/psp/journal/v2/n5/full/psp201318a.html
Holford NHG. Clinical pharmacology = disease progression + drug action. British
Journal of Clinical Pharmacology. 2013:
http://onlinelibrary.wiley.com/doi/10.1111/bcp.12170/abstract
