Dear Colleagues, It is a pleasure to invite you for the third meeting of Pharmacometrics Network Benelux. There are still some spaces available. Please mark the following date and time in your agenda : When: Thursday, November 28th - 12:30 - 18:00 Where: Astellas , Advagraf & Prograf rooms, Mirai House, Sylviusweg 62, 2333 BE Leiden, The Netherlands Agenda theme: Modeling and simulation in pediatric drug development
You can register by sending an e-mail to Petra Bitter by Monday November 25th. E-mail: [email protected]<mailto:[email protected]>. There is no registration fee, but registration is required for participation. Program 12.30 -13.25 Welcome coffee, tea and sandwiches 13.25-13.30 Introduction 13.30-14.00 Everybody wants to get the dose right!...right? Edwin Spaans, PharmD, Department of Intensive Care, ErasmusMC Sophia Children's Hospital and Kinesis Pharma BV 14.00-14.25 Predicting the efficacy of the Nanobody® ALX-0681 in pediatric patients. Massimiliano Germani, PhD, Ablynx 14.25-14.50 Scaling PK to estimate first dose in children. Ashley Strougo, PhD, Astellas 14.50-15.15 Model-based dosing rationale for darunavir when co-administered with low-dose ritonavir in pediatric HIV-1 infected patients. Anne Brochot, MSc, Janssen Pharmaceutica 15.15-15.45 Coffee/Tea break 15.45-17.00 Work in progress presentations and discussions - Pharmacokinetic modeling and dose optimization of the polyclonal antibody Thymoglobulin in pediatric patients in stem cell transplantation setting. Rick Admiraal, MD; Department of Pediatric Immunology, University Medical Center Utrecht; Division of Pharmacology, LACDR, Leiden University; Department of Pediatrics, Leiden University Medical Center, Leiden - Challenges in the prediction of dosages for new drugs in pediatric patients: the potential and limitations of application of semi-physiological models. Prof Catherijne AJ Knibbe, PharmD PhD; Division of Pharmacology, LACDR, Leiden University and St Antonius Hospital Nieuwegein -Quantitative in vitro-based pediatric PBPK predictions of tramadol: how close can we get? Huybrecht T'Jollyn, PhD candidate, Laboratory of Medical Biochemistry and Clinical Analysis, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University 17.00-17.15 Conclusion 17.15-18.00 Drinks and snacks There will be a security check when arriving at Astellas (ID required) and participant will receive a badge. Also, the parking capacity is limited so we encourage you to car pool or to use public transportation (Astellas premises are located 15 min walking from Leiden Central Station). Travelling options to Astellas Mirai House Sylviusweg 62 2333 BE Leiden The Netherlands Tel: +31 (0)71 545 5745 By car >From the direction of The Hague (N44, A44): Please follow the N44 (later the A44) from The Hague until exit 8 (Leiden, Noordwijk, Katwijk) and at the end of the exit you turn to the right. Then you follow the signs " Bio Science Park", this is the first possible turn to the left (second traffic light). After this you take the third possible turn to the right. Astellas is the first building on your left. >From the direction of Amsterdam (A4, A44): Follow the A4 and then the A44 in the direction of Leiden-West. You follow the A44 until exit 8 (Leiden, Noordwijk, Katwijk N206). After te exit you turn left under the viaduct. Then you follow the signs "Bio Science Park", this is the first possible turn to the left (second traffic light). After this you take the third possible turn to the right. Astellas is the first building on your left. If you travel with a navigation system, you will have to enter the street name Einsteinweg 1 in Leiden, because the system can't find the Sylviusweg. After that you will have to follow the last instructions as mentioned above. By public transport The train station Leiden Central is within walking distance of our new building (15 minutes). There are also two bus stops with frequent services to Leiden Central Station within 250 meters of Mirai House. Please check http://9292.nl/en#<http://9292.nl/en>. We hope to see you in Leiden on November 28! Anne Brochot Eugène Cox Rik de Greef Charlotte van Kesteren Thomas Kerbusch Catherijne Knibbe Ron Mathôt Stefaan Rossenu Jan-Stefan Van der Walt An Vermeulen On Pharmacometrics Network Benelux: the initiative aims to connect pharmacometricians in the Benelux (Belgium, Netherlands, Luxembourg). The intention is to create an informal platform for the pharmacometric community in this region of the world (in industry, academia, hospital pharmacies as well as regulatory bodies), with the goal to promote professional and scientific awareness and interactions. Stay tuned on our latest activity by joining our group on LinkedIn.
