Hello everyone, I have a curious problem with slow PRED calculations in tables. The estimations are reasonably fast, 471 seconds for 23 iterations. If there is no PRED in any tables then NONMEM finishes a moment after the message about elapsed estimation time. But if is PRED in a table then it takes an extremely long time to return, I waited more than 10 hours before I broke off the run.
If convergence of the algorithm is reasonably fast I get the impression that the differential equations are not problematic (it is $DES solved with ADVAN13 TOL=9). In fact if I restart the run with all $OMEGA to (0 FIXED) - to force all ETAs to zero - and do a MAX=0 run then it is quite fast. I would expect calculating PRED would be simply setting ETA=0 and solving the differential equations just once. Am I missing anything in how PRED in a table is calculated? Has anyone seen this kind of thing before? Any advice or tips? Warm regards, Douglas Eleveld ________________________________ De inhoud van dit bericht is vertrouwelijk en alleen bestemd voor de geadresseerde(n). Anderen dan de geadresseerde(n) mogen geen gebruik maken van dit bericht, het niet openbaar maken of op enige wijze verspreiden of vermenigvuldigen. Het UMCG kan niet aansprakelijk gesteld worden voor een incomplete aankomst of vertraging van dit verzonden bericht. The contents of this message are confidential and only intended for the eyes of the addressee(s). Others than the addressee(s) are not allowed to use this message, to make it public or to distribute or multiply this message in any way. The UMCG cannot be held responsible for incomplete reception or delay of this transferred message.
