Dear All,

 

Recently we were running some simulation/estimation using SUBPROBLEMS in
NONMEM 7.2.  In these runs we were generating covariates using a random
distribution such as the following:

 

IF(ICALL.EQ.4) THEN                                       

 COV1 = function + range*PHI(ETA(5))

COV2 = function(COV1)*EXP(ETA(4))

ENDIF

 TVKA = THETA(1)

KA   = TVKA*DEXP(ETA(1))

TVCL = THETA(2)*(COV2/X)**THETA(7)

TVV  = THETA(3)*(COV2/X)**THETA(8)

 

The NONMEM run completes, but a TABLE file is not output and the following
error is reported 

 

 

0PROGRAM TERMINATED BY NP4F

PRED RETURNS DIFFERENT OUTPUTS WITH THE SAME INPUTS

MESSAGE ISSUED FROM TABLE STEP

 

How do we avoid this error and get a table file?

We looked at the archive, and found that Dennis Fischer had asked this
question previously, but we did not see any follow-up on how to solve the
problem.  I do not remember having this issue with previous versions of
NONMEM.

 

Can anybody provide a solution to this problem?  We would greatly appreciate
it.

Best,
Matt

 

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