Have a positive effect. With one of the strongest R&D pipeline in the pharmaceutical industry, this is an exciting time to be at Pfizer. Both our Pharmacometricians and Clinical Pharmacology Leads have key roles to play in influencing the discovery and development of drugs. It's fascinating, vital work and you could be part of it. We have two new positions for talented individuals at our various sites.
Pharmacometrician at Collegeville, PA; Groton, CT or Cambridge, MA In this key role as a member of our Global Pharmacometrics group you will be responsible for providing expert study/program design, data analytical and interpretation input to our various Research and Business Unit (RU/BU) organizations. The successful candidate will work as a partner of disease area aligned multi-disciplinary teams in providing model informed drug discovery and development expertise and leadership through to loss of exclusivity. Of key importance will be the formation and maintenance of effective collaborations with amongst others, statistical, clinical and clinical pharmacology members of these teams. Pharmacometricians can provide strategic input into pre-clinical discovery, development and post-approval plans quantifying the risk associated with particular study designs or program strategies and communicating/dissemination of the results. They can use a variety of innovative quantitative methods to integrate knowledge of pharmacokinetics, a variety of response variables (including pharmacodynamic, clinical outcome and undesirable effects), patient characteristics and disease mechanism/states, statistics, study/experimental design, clinical trial simulations, model based meta-analytical evidence synthesis and techniques to facilitate quantitative decision making in order to increase RU/BU efficiency. In addition the successful candidates will forge collaborative relationships with Pharmacometric colleagues across the global Pharmacometrics community (currently based in USA, UK, China and Japan), other subject matter specialists and groups external to the organization (leading academics, external service providers etc.). Clinical Pharmacology Lead at Groton, CT; Collegeville, PA or New York, NY In this key role you will serve as the Clinical Pharmacology representative on multidisciplinary development teams and provide clinical pharmacology expertise and leadership to a project. The position entails partnering with development colleagues to integrate prior knowledge in order to develop innovative clinical development strategies and study designs for Phase 1-IV clinical trials by applying the principles of model based drug development. Clinical Pharmacology Leads work closely with clinicians and statisticians to create clinical development plans that include assessments of a drug's efficacy, safety, commercial viability and fulfilment of registration requirements. The Clinical Pharmacology Lead has primary responsibility for the clinical pharmacology components of the development plan. In order to achieve these aims, candidates are responsible for the use of innovative analytical methods to integrate knowledge of pharmacokinetics, biopharmaceutics, pharmacodynamics, patient characteristics and disease states to optimize doses, dosage regimens and study designs from proof of concept through loss of exclusivity. Both Clinical Pharmacology Leads and Pharmacometricians routinely interact with internal governance bodies, regulatory agencies and external opinions leaders. They are expected to influence the external environment by advancing their discipline and through external presentations and publications. The ideal candidates will have a doctorate degree with demonstrated expertise in clinical pharmacology and/or pharmacometrics and strong quantitative skills (e.g. experience in mechanistic modelling/systems pharmacology, quantitative translational scaling, literature model based meta-analyses, population modelling, and clinical trial simulations). We encourage applicants from different disciplines including pharmaceutical sciences, biostatistics, medicine, engineering, etc. Candidates with significant experience are sought as well as recent graduates. In addition to professional challenge, we offer a culture that supports and encourages ideas, and recognizes individual contribution. Moreover, the salary and extensive benefits are everything you'd expect from a world leading company To apply please visit the careers pages on www.pfizer.com<http://www.pfizer.com> and enter the following job opening numbers: For Pharmacometrics, job opening number: 993597 For Clinical Pharmacology Lead, job opening number: 993554
