Hi Dennis, We typically convert the dose to mg-eq of the base and account for water of hydration where appropriate (e.g. morphine sulfate pentahydrate).
Cheers... Brian From: [email protected] [mailto:[email protected]] On Behalf Of Fisher Dennis Sent: Wednesday, March 26, 2014 8:57 AM To: [email protected] Subject: [NMusers] Correcting for salt vs. base Colleagues I have been troubled by a minor issue for some time. Consider the following situation: Dose is reported in mg salt Cp is reported in ng/ml base Since CL is dose / AUC and AUC is merely the integral of Cp vs. time, in theory, dose should be converted to mg base (or concentration to ng/ml salt). However, I am not sure if everyone does that. In fact, an argument against it is that not doing the conversion permits one to relate the administered dose (which is usually based on salt) to a Cp value (usually based on base). I am interested to hear what approach people use. Dennis Dennis Fisher MD P < (The "P Less Than" Company) Phone: 1-866-PLessThan (1-866-753-7784) Fax: 1-866-PLessThan (1-866-753-7784) www.PLessThan.com<http://www.plessthan.com/> <br /><br /> ICON plc made the following annotations. ------------------------------------------------------------------------------ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835
