I prefer converting dose to the base. The advantages I see is that
the resulting PK parameter values can be more correctly interpreted
in the context of physiologic processes (hepatic blood flow, GFR,
absolute bioavailability etc).
Edmund
At 05:57 AM 3/26/2014, Fisher Dennis wrote:
Colleagues
I have been troubled by a minor issue for some time. Consider the
following situation:
Dose is reported in mg salt
Cp is reported in ng/ml base
Since CL is dose / AUC and AUC is merely the integral of Cp vs.
time, in theory, dose should be converted to mg base (or
concentration to ng/ml salt).
However, I am not sure if everyone does that.
In fact, an argument against it is that not doing the conversion
permits one to relate the administered dose (which is usually based
on salt) to a Cp value (usually based on base).
I am interested to hear what approach people use.
Dennis
Dennis Fisher MD
P < (The "P Less Than" Company)
Phone: 1-866-PLessThan (1-866-753-7784)
Fax: 1-866-PLessThan (1-866-753-7784)
<http://www.plessthan.com/>www.PLessThan.com
Edmund V. Capparelli, Pharm.D.
Professor of Clinical Pediatrics and Clinical Pharmacy
Director, Center for Research in Pediatric and Developmental
Pharmacology (RPDP)
Pediatric Pharmacology and Drug Discovery
University of California, San Diego
858-246-0009 (telephone)
858-534-5611 (fax)
