Optimal Design for Pharmacometrics 9 - 12 February 2015
Munich, Germany How do we use prior study information to improve the next study? Optimal Design does exactly this. We can predict better sampling times, better dose levels to use, the number of groups and subjects to use to achieve needed power, and more. Three of the world's top experts, Stephen Duffull, Andrew Hooker and France Mentré, in Optimal Design have created a customized four-day course to explain some of the theory behind Optimal Design, lead small group discussions on setting up, and interpreting Optimal Designs. An entire day will be devoted to hands-on examples with the PFIMOpt software. Prerequisites: Understanding of the basics of mixed effects compartmental modeling (aka, population modeling) and experience with some kind of population PKPD modeling software. Topics Include: · Introduction to the study design · Introduction to the Fisher Information Matrix (FIM) - FIM for nonlinear models and nonlinear mixed effects models - Design optimization - D-optimality, C-optimality, etc. and their interpretations · Accounting uncertainty in beliefs about the parameter and model space · Design constraints in optimization (number of samples, time ranges, groups, etc.) · Multiple response models - turnover models and others in PKPD · Maximizing the probability of experimental success, the ability to discriminate between models · An introduction to adaptive design · Handling data below the limit of quantitation · Study power and optimal design Sign up today! 20% early registration discount (Expires 8 December 2014) 30% off of groups 50% off for students Register Now. https://www.certara.com/training/classes/74 Special Rates Available at the Maritim Hotel<http://www.maritim.de/de/hotels/deutschland/hotel-muenchen/uebersicht>, http://www.maritim.de/de/hotels/deutschland/hotel-muenchen/uebersicht, if reserved by 14 December 2014 Please provide the code 1CER080215 Alicia Holmes Sales Support Specialist Certara(tm) Implementing Translational Science 210 N. Tucker Blvd., Suite 350, St. Louis, MO 63101 Tel 314-951-3012 Fax 314-951-3099 Certara: The name behind the names you know Tripos - Simcyp - Pharsight www.certara.com<http://www.certara.com/> NOTICE: The information contained in this electronic mail message is intended only for the personal and confidential use of the designated recipient(s) named above. This message may be an attorney-client communication, may be protected by the work product doctrine, and may be subject to a protective order. As such, this message is privileged and confidential. If the reader of this message is not the intended recipient or an agent responsible for delivering it to the intended recipient, you are hereby notified that you have received this message in error and that any review, dissemination, distribution, or copying of this message is strictly prohibited. If you have received this communication in error, please notify us immediately by telephone and e-mail and destroy any and all copies of this message in your possession (whether hard copies or electronically stored copies). Thank you. buSp9xeMeKEbrUze
