Merck Serono is the biopharmaceutical division of Merck At Merck Serono, we discover, develop, manufacture and market innovative small molecules and biopharmaceuticals in our focus therapeutic areas:
* Oncology * Neurodegenerative diseases * Fertility * Endocrinology * CardioMetabolic Care With headquarter in Darmstadt, Germany, and over 16,000 people worldwide, we're active on all continents and offer leading brands in 150 countries. In the United States and Canada, EMD Serono operates through separately incorporated affiliates. Merck Serono is seeking a creative, motivated scientist to join our Pharmacometric department in Darmstadt (Germany). Position Title Senior Scientist, Modeling & Simulation To apply please visit the careers pages on https://career012.successfactors.eu/career?company=merckgroup and enter the Requisition ID: 41221. PURPOSE OF THE ROLE To develop M&S methodologies and expertise in drug development and make them available to facilitate more efficient and informative clinical trials, inform decision making, and globally support Enabling Clinical Science, TIPs, Clinical Development, Clinical Teams and Projects. KEY TASKS & RESPONSIBILITIES * Globally support the Quantitative Pharmacology department within Global Early Development * Provide M&S input into Clinical Development Plans * Participate to sound translational science, from animal to healthy subjects, to patients, to special populations * Plan, perform, interpret, present, track and record M&S-related activities within allocated projects and studies * Keep up-to-date with scientific development in M&S, and regulatory guidance and trends * Develop internal expertise in advanced population PKPD modeling, with emphasis on physiological and mechanistic approaches * Explore, evaluate and implement appropriate pharmacometric tools and methodologies; participate to the improvement of the M&S processes and technological platform * Representation of the whole of Quantitative Pharmacology in transactions with internal and external stakeholders EDUCATION/LANGUAGES * Master or higher degree in Clinical Sciences related disciplines (Medicine, Physiology, Pharmaceutical Sciences, etc) and strong expertise in Pharmacometrics/biostatistics. Alternatively, degree in Mathematics/Statistics and strong experience in clinical development. * Fluent in written and oral English * Fluency in other European languages, particularly German, is an asset * PROFESSIONAL SKILLS & EXPERIENCE * 3+ years experience in PKPD Modeling, of which 1+ in BioPharmaceutical Industry. * PKPD M&S input into drug development. * Good command of NONMEM is an absolute prerequisite, experience with MONOLIX is an asset. * Good command of R is an absolute prerequisite, experience with SAS is an asset. * Experience with PsN and Xpose is another asset. * Experience with Clinical Trial Simulation tools is another asset, alike for other analytical/modeling/ optimization/presentation software or language, e.g. ADAPT, SAAM II, BERKELEY MADONA, SIMCYP * Experience in writing and using PKPD models, particularly mechanistic-models and in developing disease progression models is an asset. * Overall good knowledge of common PC software. PERSONAL SKILLS & COMPETENCIES * Strong problem solving skills and ability to analyze complex problems * Has interest in, and knowledge of, both mathematical and (patho-)physiological aspects of M&S in drug development * Is enthusiastic, self-motivated and has good communication skills, and at ease in working in a dynamic matrix organization; is a team-player. Communicate technical details effectively with scientists and clinicians colleagues To apply please visit the careers pages on https://career012.successfactors.eu/career?company=merckgroup and enter the following Requisition ID 41221. With best regards, Pascal Girard Director, Modeling & Simulation Merck Serono | Global Early Development "Merck - Living Innovation" http://www.merckserono.com/en/careers/about_merck_serono/about_merck_serono.html This message and any attachment are confidential and may be privileged or otherwise protected from disclosure. If you are not the intended recipient, you must not copy this message or attachment or disclose the contents to any other person. If you have received this transmission in error, please notify the sender immediately and delete the message and any attachment from your system. Merck KGaA, Darmstadt, Germany and any of its subsidiaries do not accept liability for any omissions or errors in this message which may arise as a result of E-Mail-transmission or for damages resulting from any unauthorized changes of the content of this message and any attachment thereto. Merck KGaA, Darmstadt, Germany and any of its subsidiaries do not guarantee that this message is free of viruses and does not accept liability for any damages caused by any virus transmitted therewith. Click http://www.merckgroup.com/disclaimer to access the German, French, Spanish and Portuguese versions of this disclaimer.
