Colleagues

Running NONMEM 7.3 in OS X, I just encountered the following message:

0THE INPUT MATRIX IS SINGULAR. SOME OF THE DIAGONAL ELEMENTS OF THE UPPER
          TRIANGULAR MATRIX U OF THE LU FACTORIZATION ARE CLOSE TO ZERO.

Of note, a Google search yields a hit to Bill Bachman’s reply to an email that 
I sent to this user group in 2010 (but no explanation)

Can anyone explain the message?

Dennis

Dennis Fisher MD
P < (The "P Less Than" Company)
Phone: 1-866-PLessThan (1-866-753-7784)
Fax: 1-866-PLessThan (1-866-753-7784)
www.PLessThan.com <http://www.plessthan.com/>



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