Ana: The most common reason NONMEM may produce a different result than expected is if the evaluation depends on covariates listed in the data set that changes with each record, the default action of NONMEM is for an interval covering T1>Time<=T2, it uses the covariate at record TIME=T2. This behavior can be changed with $BIND. Also, if you program in discontinuities that vary with model parameters, like changing a rate constant suddenly, you may want to use the MTIME() system. Both of these items are discussed in viii.pdf.
Robert J. Bauer, Ph.D. Vice President, Pharmacometrics R&D ICON Early Phase Office: (215) 616-6428 Mobile: (925) 286-0769 [email protected]<mailto:[email protected]> www.iconplc.com<http://www.iconplc.com> From: [email protected] [mailto:[email protected]] On Behalf Of Nick Holford Sent: Thursday, January 21, 2016 11:33 AM To: [email protected] Subject: Re: [NMusers] NONMEM code verification Ana, I call this process fixed effect (or deterministic) model qualification. I code complex models using Berkeley Madonna then run NONMEM without any $EST or $SIM records. The NONMEM PRED values should agree with the Berkeley Madonna predictions if your structural model is coded the same way in both systems. Best wishes, Nick On 20-Jan-16 11:14, Ana Miranda Bastos wrote: > > Hi, > > > I have a complex model with manually coded ODEs and multiple > compartments. VPC etc seem ok but simulation results are getting a bit > weird. > > > I'd like to find out what people use to ensure that the NONMEM code > written really represents the set of ODEs written on paper. Just to > clarify, this is just to make sure the NONMEM instructions are > actually a correct representation of the mathematical description of > the model, not if the model is a correct representation of the biology > at this stage. > > > This problem is not so obvious when you use the built-in macros but > once the model grows complex, and has a lot manual inputs, it is more > likely that a bug creeps in. > > > I'm looking for something more stringent than a code review by a peer. > > > Thank you advance for your time and attention, > > > Ana > > > ------------------------------------------ > Ana Bastos, Pharm, MSc, PhD student > Pharmacologie cellulaire et moléculaire > (Cellular and Molecular Pharmacology Unit) > Louvain Drug Research Institute > Université catholique de Louvain (Catholic University of Louvain) > UCL 7370 avenue E. Mounier 73 > 1200 Bruxelles, Belgique > -- Nick Holford, Professor Clinical Pharmacology Dept Pharmacology & Clinical Pharmacology, Bldg 503 Room 302A University of Auckland,85 Park Rd,Private Bag 92019,Auckland,New Zealand office:+64(9)923-6730 mobile:NZ+64(21)46 23 53 email: [email protected]<mailto:[email protected]> http://holford.fmhs.auckland.ac.nz/<http://holford.fmhs.auckland.ac.nz/> "Declarative languages are a form of dementia -- they have no memory of events" Holford SD, Allegaert K, Anderson BJ, Kukanich B, Sousa AB, Steinman A, Pypendop, B., Mehvar, R., Giorgi, M., Holford,N.H.G. Parent-metabolite pharmacokinetic models - tests of assumptions and predictions. Journal of Pharmacology & Clinical Toxicology. 2014;2(2):1023-34. Holford N. Clinical pharmacology = disease progression + drug action. Br J Clin Pharmacol. 2015;79(1):18-27. <br /><br /> ICON plc made the following annotations. ------------------------------------------------------------------------------ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835
