Swati, Did you run a model without additive RUV and checked if it is required?
Best Regards, Ayyappa > On Jan 21, 2016, at 2:44 AM, swati j <swatijaiswal....@gmail.com> wrote: > > Dear members of nmusers: > I am trying to do PopPK analysis of plasma concentration-time data obtained > from a non-steady-state PK study of a drug in hamsters (at 2 doses; 10 mg/kg > and 20 mg/kg, p.o for 5 consecutive days at interval of 24 hr). > after executing the model file(one compartment model with first order > absorption), the result indicated successful minimization, but with one > WARNING messgae : > "Large relative standard errors found, > additive RUV 0.363451" > Please suggest What should I do next?....How I can reduce the RSE and what > should be my next step to improve the model > the model file which i used is as follows > $PROBLEM PK model 1cmt > $INPUT ID TIME DV AMT ADDL II MDV > $DATA paginPK4.csv IGNORE=# > $SUBROUTINE ADVAN2 TRANS2 > $PK > KA=THETA(1)*EXP(ETA(1)) > CL=THETA(2)*EXP(ETA(2)) > V =THETA(3) > SC=V/1000 > STRT = 0 > $THETA (0,0.338111) ; KA > (0,11.4608) ; CL total > (0,1049.2) ; V2 > $OMEGA 0.0423895 ; KA > 0.0143127 ; cl > $SIGMA 0.0640523 ; proportional RUV > 0.00105349 ; additive RUV > $ERROR > IPRED = F > IRES = DV-IPRED > W = DV > IWRES = IRES/W > Y = IPRED*(1+EPS(1)) + EPS(2) > > $ESTIMATION METHOD=1 INTERACTION MAXEVAL=9999 SIG=3 PRINT=5 NOABORT > POSTHOC > $COVARIANCE PRINT=E > ;$SIM (1234) NSUBPROBLEMS=1 ONLYSIM > $TABLE ID TIME DV PRED IPRED RES WRES IRES IWRES CL V KA AMT DV > NOAPPEND NOPRINT ONEHEADER FILE=out8.tab ; Xpose > $TABLE ID TIME DV IPRED IRES IWRES CWRES NOPRINT ONEHEADER > FILE=sdtab8 > $TABLE ID KA CL V NOPRINT ONEHEADER FILE=patab8 > $TABLE ID NOPRINT ONEHEADER FILE=cotab8 > $TABLE ID NOPRINT ONEHEADER FILE=catab8 > thanks in advance > > Regards > Swati > Swati Jaiswal > PhD Scholar (CSIR-Senior Research Fellow) > Pharmacokinetics & Metabolism Division > CSIR-Central Drug Research Institute > Lucknow-226031, India > Mobile +91 9473837970
