Hi Mark,
Might you have more than one $EST step where Laplacian is not used in
one of them? And, can you share your $EST step options?
Thanks,
Bill
On 7/17/2016 4:28 PM, Mark Sale wrote:
Question:
NONMEM has a function to run a grid search to obtain initial estimates
for THETA. But, when I try to do this with BQL data/Laplacian I get
this run time error message:
0PROGRAM TERMINATED BY OBJ
WITH INDIVIDUAL 1 ID= 1.00000000000000E+00 DATA REC. 13
WITH NMPR17, LAPLACIAN ESTIMATION METHOD MUST BE USED
It seems the Laplacian isn't used for the grid search for initial
estimates (even though specified in $EST).
any ideas?
Mark Sale M.D.
Vice President, Modeling and Simulation
Nuventra Pharma Sciences, Inc.
2525 Meridian Parkway, Suite 280
Durham, NC 27713
Phone (919)-973-0383
[email protected] <[email protected]>
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